ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB

Stable Identifier
R-HSA-8931858
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Electron transfer flavoprotein beta subunit lysine methyltransferase (ETFBKMT, METTL20) specifically methylates Lys-200 and Lys-203 of Electron transfer flavoprotein beta (ETFB) ) (Rhein et al 2014, Malecki et al. 2015). ETF shuttles electrons between several FAD-containing dehydrogenases present in the mitochondrial matrix and the membrane-bound ETF:quinone oxidoreductase (Ramsay et al. 1987). ETFB is proposed to contain 'recognition loop' at residues 191–200, responsible for interaction with the dehydrogenases (Toogood et al. 2004). Methylation of ETF impairs its ability to extract electrons from two acyl-CoA dehydrogenases, MCAD and GCDH, suggesting a functional role for ETFBKMT-mediated methylation of ETFB (Malecki et al. 2015).

Literature References
PubMed ID Title Journal Year
25416781 Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity

Małecki, J, Ho, AY, Moen, A, Dahl, HA, Falnes, PØ

J. Biol. Chem. 2015
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Catalyst Activity
Title
protein-lysine N-methyltransferase activity of ETFBKMT [mitochondrial matrix]
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