CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3

Stable Identifier
R-HSA-8878130
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3
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Transcription of the CDKN1A (p21) gene is synergistically stimulated by RUNX3 and ZFHX3 (ATBF1), presumably through formation of the complex between RUNX3 and ZFHX3. RUNX3 and ZFHX3 can also stimulate CDKN1A transcription independently of one another, albeit to a lower level than when they act in tandem (Mabuchi et al. 2010).
Literature References
PubMed ID Title Journal Year
20599712 Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction

Kubota, E, Mori, Y, Mizoshita, T, Tanaka, M, Kawaguchi, M, Mizushima, T, Miura, Y, Kim, TS, Kataoka, H, Ebi, M, Asai, K, Joh, T, Tanida, S, Shimura, T, Mabuchi, M, Kamiya, T

Biochem. Biophys. Res. Commun. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX3:ZFHX3 [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-06-30)
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