CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3

Stable Identifier
Reaction [omitted]
Homo sapiens
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Transcription of the CDKN1A (p21) gene is synergistically stimulated by RUNX3 and ZFHX3 (ATBF1), presumably through formation of the complex between RUNX3 and ZFHX3. RUNX3 and ZFHX3 can also stimulate CDKN1A transcription independently of one another, albeit to a lower level than when they act in tandem (Mabuchi et al. 2010).

Literature References
PubMed ID Title Journal Year
20599712 Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction

Mabuchi, M, Kataoka, H, Miura, Y, Kim, TS, Kawaguchi, M, Ebi, M, Tanaka, M, Mori, Y, Kubota, E, Mizushima, T, Shimura, T, Mizoshita, T, Tanida, S, Kamiya, T, Asai, K, Joh, T

Biochem. Biophys. Res. Commun. 2010
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