Reactome | p-S249,T273,S276-RUNX1 [nucleoplasm]

p-S249,T273,S276-RUNX1 [nucleoplasm]

Stable Identifier

R-HSA-8878063

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S249,T273,S276-AML1

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External Reference Information

External Reference

UniProt:Q01196 RUNX1

Gene Names

RUNX1, AML1, CBFA2

Chain

chain:1-453

Reference Genes

BioGPS Gene:861 RUNX1

COSMIC (genes):RUNX1 RUNX1

CTD Gene:861 RUNX1

dbSNP Gene:861 RUNX1

ENSEMBL:ENSG00000159216 RUNX1

HGNC:10471 RUNX1

KEGG:hsa:861 RUNX1

Monarch:861 RUNX1

NCBI Gene:861 RUNX1

OMIM:151385 RUNX1

UCSC:Q01196 RUNX1

Reference Transcript

Participates

as a component of

p-S249,S273,S276-RUNX1:CBFB [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RUNX1 [nucleoplasm]

MeR206,MeR210-RUNX1 [nucleoplasm]

p-7Y-RUNX1 [nucleoplasm]

RUNX1 [plasma membrane]

Inferred To

phospho-RUNX1 [nucleoplasm] (Gallus gallus)

phospho-run [nucleoplasm] (Drosophila melanogaster)

phospho-p-S249,T273,S276-RUNX1 [nucleoplasm] (Bos taurus)

phospho-p-S249,T273,S276-RUNX1 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S249,T273,S276-RUNX1 [nucleoplasm] (Canis familiaris)

phospho-p-S249,T273,S276-RUNX1 [nucleoplasm] (Mus musculus)

phospho-p-S249,T273,S276-RUNX1 [nucleoplasm] (Rattus norvegicus)

phospho-p-S249,T273,S276-RUNX1 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 249

Coordinate

249

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 273

Coordinate

273

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 276

Coordinate

276

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001116079.1, XP_011528068.1, XP_005261125.1, NP_001745.2, NP_001001890.1

OpenTargets

ENSG00000159216

ENSEMBL

ENST00000358356, ENSP00000300305, ENST00000344691, ENST00000300305, ENSP00000340690, ENSP00000351123, ENSG00000159216, ENST00000675419, ENSP00000501943

HPA

ENSG00000159216-RUNX1

GeneCards

RUNX1

PRO

Q01196

Pharos - Targets

Q01196

Orphanet

RUNX1

GlyGen

Q01196

PDB

1LJM, 1E50, 1H9D, 1CO1, 1CMO

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13951 CBFB	1	CBFB [nucleoplasm] (R-HSA-8865293)	0.872	7
UniProt:Q9H2X6 HIPK2	3	monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405) HIPK2 [nucleoplasm] (R-HSA-3215222) p-HIPK2 [nucleoplasm] (R-HSA-6799375)	0.639	4
UniProt:Q00534 CDK6	3	p-T177-CDK6 [nucleoplasm] (R-HSA-69628) CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336)	0.628	5
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.623	3
UniProt:Q15723 ELF2	1	ELF2 [nucleoplasm] (R-HSA-8938898)	0.544	2
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.527	2

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