RUNX1:CBFB binds EP300

Stable Identifier
R-HSA-8878056
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The complex of CBFB and RUNX1 can bind histone acetyltransferase EP300 (p300). Formation of this complex does not depend on HIPK2-mediated phosphorylation of RUNX1. Histone acetyltransferase activity of EP300 probably contributes to transcriptional activation of RUNX1:CBFB target genes (Aikawa et al. 2006, Wee et al. 2008).
Literature References
PubMed ID Title Journal Year
18695000 PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

Ito, Y, Voon, DC, Wee, HJ, Bae, SC

Blood 2008
16917507 Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

Koseki, H, Schmitz, ML, Nguyen, LA, Takakura, N, Isono, K, Tagata, Y, Kitabayashi, I, Aikawa, Y

EMBO J. 2006
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