SMAD6 gene expression is stimulated by RUNX2 and SMAD1

Stable Identifier
R-HSA-8878023
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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SMAD6 gene expression is stimulated by RUNX2 and SMAD1
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Binding of the complex of RUNX2 and SMAD1 to the promoter of the SMAD6 gene positively regulates SMAD6 transcription (Wang et al. 2007).

Literature References
PubMed ID Title Journal Year
17215250 Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2

Wang, Q, Xing, L, Zhang, M, Zhu, T, Shen, R, O'Keefe, RJ, Chen, D, Wei, X

J. Biol. Chem. 2007
Participants
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Output
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as an event of
This event is regulated
Positively by
Regulator
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4:SMAD6 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-06-29)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-06-29)
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