Reactome | GGC-RAB38 [melanosome membrane]

GGC-RAB38 [melanosome membrane]

Stable Identifier

R-HSA-8877740

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

melanosome membrane

Synonyms

Ras-related protein Rab-38, RAB38_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P57729 RAB38

Gene Names

RAB38

Chain

chain:1-211

Reference Genes

BioGPS Gene:23682 RAB38

COSMIC (genes):RAB38 RAB38

CTD Gene:23682 RAB38

dbSNP Gene:23682 RAB38

ENSEMBL:ENSG00000123892 RAB38

ENSEMBL_homo_sapiens_GENE:ENSG00000123892.12 RAB38

HGNC:9776 RAB38

KEGG Gene (Homo sapiens):23682 RAB38

Monarch:23682 RAB38

NCBI Gene:23682 RAB38

OMIM:606281 RAB38

UCSC:P57729 RAB38

Reference Transcript

RefSeq:NM_022337.2 RAB38

Other Identifiers

11724146_at

11724147_at

11757999_s_at

16743104

219412_PM_at

219412_at

23682

3385753

3385754

3385755

3385757

3385760

3385761

3385762

3385763

56894_at

7950899

A_23_P161563

GE62028

GO:0000166

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005737

GO:0005739

GO:0005764

GO:0005768

GO:0005769

GO:0005773

GO:0005794

GO:0005802

GO:0005829

GO:0005886

GO:0006629

GO:0006886

GO:0007005

GO:0007264

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0023052

GO:0030154

GO:0030670

GO:0030742

GO:0031410

GO:0031982

GO:0032438

GO:0033162

GO:0035646

GO:0035650

GO:0035651

GO:0036461

GO:0042470

GO:0043226

GO:0043231

GO:0044233

GO:0044297

GO:0045335

GO:0048023

GO:0048471

GO:0060155

GO:0072657

GO:0090383

GO:1903232

GO:1904377

GO:2001247

HMNXSV003056950

ILMN_2134974

PH_hs_0006020

TC11002174.hg

g11641236_3p_at

Participates

as a member of

RAB32,RAB38 [melanosome membrane] (Homo sapiens)

Other forms of this molecule

GGC-RAB38 [cytosol]

RAB38 [cytosol]

Inferred To

Rab32 [melanosome membrane] (Drosophila melanogaster)

glo-1 [melanosome membrane] (Caenorhabditis elegans)

Rab38 [melanosome membrane] (Rattus norvegicus)

GGC-RAB38 [melanosome membrane] (Danio rerio)

GGC-RAB38 [melanosome membrane] (Dictyostelium discoideum)

GGC-RAB38 [melanosome membrane] (Gallus gallus)

GGC-RAB38 [melanosome membrane] (Mus musculus)

GGC-RAB38 [melanosome membrane] (Saccharomyces cerevisiae)

GGC-RAB38 [melanosome membrane] (Sus scrofa)

Homologues of GGC-RAB38 [melanosome membrane] (Dictyostelium discoideum)

RAB38 [melanosome membrane] (Bos taurus)

RAB38 [melanosome membrane] (Canis familiaris)

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 208

Coordinate

208

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_071732.1

OpenTargets

ENSG00000123892

GeneCards

P57729

HPA

ENSG00000123892-RAB38

Ensembl

ENSG00000123892, ENST00000243662, ENSP00000243662

PRO

P57729

Pharos - Targets

P57729

PDB

6S5H, 6HDU

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.683	7
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.558	4
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3