Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DENND1A [cytosol]
Stable Identifier
R-HSA-8877594
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="25"DENN domain-containing protein 1A, DEN1A_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Homo sapiens)
DENND1A, DENND1B [cytosol] (Homo sapiens)
DENND1A [cytosol] (Homo sapiens)
DENND1s exchange GTP for GDP on RAB35 (Homo sapiens)
RAB35 GEFs [cytosol] (Homo sapiens)
DENND1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TEH3 DENND1A
Gene Names
DENND1A, FAM31A, KIAA1608
Chain
chain:1-1009
Reference Genes
BioGPS Gene:57706 DENND1A
COSMIC (genes):DENND1A DENND1A
CTD Gene:57706 DENND1A
dbSNP Gene:57706 DENND1A
ENSEMBL:ENSG00000119522 DENND1A
ENSEMBL_homo_sapiens_GENE:ENSG00000119522.18 DENND1A
HGNC:29324 DENND1A
KEGG Gene (Homo sapiens):57706 DENND1A
Monarch:57706 DENND1A
NCBI Gene:57706 DENND1A
OMIM:613633 DENND1A
UCSC:Q8TEH3 DENND1A
Reference Transcript
RefSeq:NM_020946.1 DENND1A
RefSeq:NM_024820.2 DENND1A
Other Identifiers
11726215_a_at
11748929_a_at
11755028_a_at
17098222
219763_PM_at
219763_at
226849_PM_at
226849_at
3224651
3224652
3224653
3224654
3224655
3224656
3224657
3224671
3224672
3224673
3224674
3224677
3224682
3224700
3224702
3224704
3224705
3224707
3224708
3224733
3224742
3224754
3224763
3224767
3224774
3224777
3224779
3224805
3224806
3224809
3224820
3224833
3224845
56159_at
57706
64728_at
64729_g_at
71795_at
8164034
92001_at
A_23_P43557
A_24_P272761
A_32_P23854
GO:0005085
GO:0005829
GO:0005886
GO:0006897
GO:0008289
GO:0015031
GO:0016020
GO:0016192
GO:0023052
GO:0030136
GO:0030665
GO:0031410
GO:0032266
GO:0032456
GO:0032483
GO:0042734
GO:0042995
GO:0043226
GO:0043231
GO:0045202
GO:0098772
GO:1901981
HMNXSV003016367
HMNXSV003030517
Hs.300842.1.S1_3p_at
ILMN_1727315
ILMN_1728073
ILMN_1753275
PH_hs_0015485
PH_hs_0032567
TC09001571.hg
g13449264_3p_at
Participates
as a member of
RAB35 GEFs [cytosol] (Homo sapiens)
DENND1A, DENND1B [cytosol] (Homo sapiens)
Other forms of this molecule
p-S536, S538 DENND1A [cytosol]
Inferred To
dennd1a [cytosol]
(Xenopus tropicalis)
DENND1A [cytosol]
(Bos taurus)
DENND1A [cytosol]
(Canis familiaris)
DENND1A [cytosol]
(Dictyostelium discoideum)
DENND1A [cytosol]
(Gallus gallus)
DENND1A [cytosol]
(Sus scrofa)
CG30347 [cytosol]
(Drosophila melanogaster)
rme-4 [cytosol]
(Caenorhabditis elegans)
Dennd1a [cytosol]
(Mus musculus)
Dennd1a [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_079096.2
,
NP_065997.1
OpenTargets
ENSG00000119522
GeneCards
Q8TEH3
HPA
ENSG00000119522-DENND1A
Ensembl
ENSP00000362720
,
ENSG00000119522
,
ENST00000373618
,
ENST00000373624
,
ENSP00000362727
,
ENST00000373620
,
ENSP00000362722
PRO
Q8TEH3
Pharos - Targets
Q8TEH3
PDB
6EKK
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.483
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.483
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.483
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text