MON1:CCZ1 exchanges GTP for GDP on RAB7

Stable Identifier
Reaction [transition]
Homo sapiens
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RAB7 acts downstream of RAB5 in a RAB cascade that regulates endolysosomal trafficking (Chavrier et al, 1990; Feng et al, 1997; Vitelli et al, 1997; reviewed in Epp et al, 2011; Solinger and Spang, 2013). The RAB7 GEF complex, MON:CCZ1, is recruited to the endosome through interaction with RAB5 and the RAB5 effector complex CORVET (Nordmann et al, 2010; Gerondopolous et al, 2012; Poteryaev et al, 2010; Wang et al, 2002; Kinchen and Ravichandran, 2010; reviewed in Wang et al, 2011; Balderhaar and Ungermann, 2013). Recruitment of MON1:CCZ1 leads to the displacement RAB5 and the RAB5 GEF RABEX5, and subsequent recruitment and activation of RAB7 (Poteryaev et al, 2010; reviewed in Balderhaar and Ungermann, 2013; Wandinger-Ness and Zerial, 2014; Ishida et al, 2016). RAB7 is also involved in more specialized trafficking pathways involved in phagocytosis, autophagy and retromer-mediated endocytosis, among others (Gutierrez et al, 2004; Harrison et al, 2003; Cantalupo et al, 2003; reviewed in Hyttinen et al, 2013)

Literature References
PubMed ID Title Journal Year
20305638 Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

Kinchen, JM, Ravichandran, KS

Nature 2010
20797862 The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7

Engelbrecht-Vandré, S, Ostrowicz, C, Perz, A, Ungermann, C, Bröcker, C, Nordmann, M, Cabrera, M

Curr. Biol. 2010
21683469 Membrane dynamics and fusion at late endosomes and vacuoles--Rab regulation, multisubunit tethering complexes and SNAREs

Epp, N, Krämer, L, Ungermann, C, Rethmeier, R

Eur. J. Cell Biol. 2011
2115402 Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

Parton, RG, Hauri, HP, Zerial, M, Chavrier, P, Simons, K

Cell 1990
23645161 CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

Balderhaar, HJ, Ungermann, C

J. Cell. Sci. 2013
15138286 Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

Colombo, MI, Gutierrez, MG, Munafó, DB, Berón, W

J. Cell. Sci. 2004
20434987 Identification of the switch in early-to-late endosome transition

Spang, A, Zerial, M, Datta, S, Poteryaev, D, Ackema, K

Cell 2010
12364329 The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways

Stromhaug, PE, Klionsky, DJ, Shima, J, Wang, CW

J. Biol. Chem. 2002
9020161 Role of the small GTPase Rab7 in the late endocytic pathway

Vitelli, R, Bucci, C, Bruni, CB, Bifulco, M, Chiariello, M, Santillo, M, Lattero, D

J. Biol. Chem. 1997
23220125 Maturation of autophagosomes and endosomes: a key role for Rab7

Niittykoski, M, Kaarniranta, K, Salminen, A, Hyttinen, JM

Biochim. Biophys. Acta 2013
11179213 Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes

Alifano, P, Roberti, V, Bucci, C, Bruni, CB, Cantalupo, G

EMBO J. 2001
23351085 Tethering complexes in the endocytic pathway: CORVET and HOPS

Spang, A, Solinger, JA

FEBS J. 2013
23084991 BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor

Linford, A, Barr, FA, Liang, JR, Gerondopoulos, A, Langemeyer, L

Curr. Biol. 2012
20851765 Rab7: role of its protein interaction cascades in endo-lysosomal traffic

Hong, W, Ming, Z, Wang, T, Xiaochun, W

Cell. Signal. 2011
12944476 Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP

Schroer, TA, Vieira, OV, Harrison, RE, Grinstein, S, Bucci, C

Mol Cell Biol 2003
25341920 Rab proteins and the compartmentalization of the endosomal system

Wandinger-Ness, A, Zerial, M

Cold Spring Harb Perspect Biol 2014
8522602 Rab 7: an important regulator of late endocytic membrane traffic

Press, B, Feng, Y, Wandinger-Ness, A

J. Cell Biol. 1995
27246931 Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases

Oguchi, ME, Fukuda, M, Ishida, M

Cell Struct. Funct. 2016
Catalyst Activity

guanyl-nucleotide exchange factor activity of MON1:CCZ1 [cytosol]

Orthologous Events
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