Reactome | MON1:CCZ1 exchanges GTP for GDP on RAB7

MON1:CCZ1 exchanges GTP for GDP on RAB7

Stable Identifier

R-HSA-8877451

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal membrane, cytosol

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RAB7 acts downstream of RAB5 in a RAB cascade that regulates endolysosomal trafficking (Chavrier et al, 1990; Feng et al, 1997; Vitelli et al, 1997; reviewed in Epp et al, 2011; Solinger and Spang, 2013). The RAB7 GEF complex, MON:CCZ1, is recruited to the endosome through interaction with RAB5 and the RAB5 effector complex CORVET (Nordmann et al, 2010; Gerondopolous et al, 2012; Poteryaev et al, 2010; Wang et al, 2002; Kinchen and Ravichandran, 2010; reviewed in Wang et al, 2011; Balderhaar and Ungermann, 2013). Recruitment of MON1:CCZ1 leads to the displacement RAB5 and the RAB5 GEF RABEX5, and subsequent recruitment and activation of RAB7 (Poteryaev et al, 2010; reviewed in Balderhaar and Ungermann, 2013; Wandinger-Ness and Zerial, 2014; Ishida et al, 2016). RAB7 is also involved in more specialized trafficking pathways involved in phagocytosis, autophagy and retromer-mediated endocytosis, among others (Gutierrez et al, 2004; Harrison et al, 2003; Cantalupo et al, 2003; reviewed in Hyttinen et al, 2013)

Literature References

PubMed ID	Title	Journal	Year
20797862	The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7 Nordmann, M, Cabrera, M, Perz, A, Bröcker, C, Ostrowicz, C, Engelbrecht-Vandré, S, Ungermann, C	Curr. Biol.	2010
20305638	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells Kinchen, JM, Ravichandran, KS	Nature	2010
21683469	Membrane dynamics and fusion at late endosomes and vacuoles--Rab regulation, multisubunit tethering complexes and SNAREs Epp, N, Rethmeier, R, Krämer, L, Ungermann, C	Eur. J. Cell Biol.	2011
2115402	Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments Chavrier, P, Parton, RG, Hauri, HP, Simons, K, Zerial, M	Cell	1990
23645161	CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion Balderhaar, HJ, Ungermann, C	J. Cell. Sci.	2013
15138286	Rab7 is required for the normal progression of the autophagic pathway in mammalian cells Gutierrez, MG, Munafó, DB, Berón, W, Colombo, MI	J. Cell. Sci.	2004
20434987	Identification of the switch in early-to-late endosome transition Poteryaev, D, Datta, S, Ackema, K, Zerial, M, Spang, A	Cell	2010
12364329	The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways Wang, CW, Stromhaug, PE, Shima, J, Klionsky, DJ	J. Biol. Chem.	2002
9020161	Role of the small GTPase Rab7 in the late endocytic pathway Vitelli, R, Santillo, M, Lattero, D, Chiariello, M, Bifulco, M, Bruni, CB, Bucci, C	J. Biol. Chem.	1997
23220125	Maturation of autophagosomes and endosomes: a key role for Rab7 Hyttinen, JM, Niittykoski, M, Salminen, A, Kaarniranta, K	Biochim. Biophys. Acta	2013
11179213	Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes Cantalupo, G, Alifano, P, Roberti, V, Bruni, CB, Bucci, C	EMBO J.	2001
23351085	Tethering complexes in the endocytic pathway: CORVET and HOPS Solinger, JA, Spang, A	FEBS J.	2013
23084991	BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor Gerondopoulos, A, Langemeyer, L, Liang, JR, Linford, A, Barr, FA	Curr. Biol.	2012
20851765	Rab7: role of its protein interaction cascades in endo-lysosomal traffic Wang, T, Ming, Z, Xiaochun, W, Hong, W	Cell. Signal.	2011
12944476	Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP Harrison, RE, Bucci, C, Vieira, OV, Schroer, TA, Grinstein, S	Mol Cell Biol	2003
25341920	Rab proteins and the compartmentalization of the endosomal system Wandinger-Ness, A, Zerial, M	Cold Spring Harb Perspect Biol	2014
8522602	Rab 7: an important regulator of late endocytic membrane traffic Feng, Y, Press, B, Wandinger-Ness, A	J. Cell Biol.	1995
27246931	Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases Ishida, M, Oguchi, ME, Fukuda, M	Cell Struct. Funct.	2016