FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter

Stable Identifier
R-HSA-8877414
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The complex of FOXP3 and the RUNX1:CBFB heterodimer binds the promoter of the CTLA4 gene (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).
Literature References
PubMed ID Title Journal Year
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Rao, A, Ziegler, SF, Heissmeyer, V, Stroud, JC, Bates, DL, Guo, L, Mathis, D, Chen, L, Han, A, Wu, Y, Lapan, AD, Feuerer, M, Borde, M, Benoist, C

Cell 2006
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Nagamura, Y, Ono, M, Kitabayashi, I, Tsukada, T, Ohkura, N, Sakaguchi, S, Nomura, T, Yaguchi, H, Miyachi, Y

Nature 2007
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-06-22)
Cite Us!