FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter

Stable Identifier
R-HSA-8877414
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter
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The complex of FOXP3 and the RUNX1:CBFB heterodimer binds the promoter of the CTLA4 gene (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).

Literature References
PubMed ID Title Journal Year
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Rao, A, Ziegler, SF, Heissmeyer, V, Stroud, JC, Bates, DL, Guo, L, Mathis, D, Chen, L, Han, A, Wu, Y, Lapan, AD, Feuerer, M, Borde, M, Benoist, C

Cell 2006
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Nagamura, Y, Ono, M, Kitabayashi, I, Tsukada, T, Ohkura, N, Sakaguchi, S, Nomura, T, Yaguchi, H, Miyachi, Y

Nature 2007
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Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-06-22)
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