IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3

Stable Identifier
R-HSA-8877345
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The RUNX1:CBFB complex in cooperation with NFATC2 (NFAT1) stimulates transcription of the IL2 gene. In the presence of FOXP3, however, transcription of the IL2 gene is suppressed. Suppressed IL2 production is one of the hallmarks of regulatory T cells (Tregs) (Wu et al. 2006, Ono et al. 2007).
Literature References
PubMed ID Title Journal Year
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Rao, A, Ziegler, SF, Heissmeyer, V, Stroud, JC, Bates, DL, Guo, L, Mathis, D, Chen, L, Han, A, Wu, Y, Lapan, AD, Feuerer, M, Borde, M, Benoist, C

Cell 2006
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Nagamura, Y, Ono, M, Kitabayashi, I, Tsukada, T, Ohkura, N, Sakaguchi, S, Nomura, T, Yaguchi, H, Miyachi, Y

Nature 2007
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