CBL-like E3 ubiquitin ligase Hakai (CBLL1) ubiquitinates the E-cadherin complex engaged by binding of E-cadherin (CDH1) to internalin (InlA), a cell wall protein of Listeria monocytogenes. CBLL1 ubiquitinates both CDH1 and CDH1-bound beta-catenin (CTNNB1), triggering endocytosis of the InlA-bound CDH1 complex and entry of bacteria to host cells. It appears that both clathrin-mediated and caveolin-mediated endocytosis contribute to invasion of host cells by Listeria monocytogenes via the InlA-CDH1 route (Bonazzi et al. 2008).CBLL1 may undergo SRC-mediated phosphorylation and subsequent auto-ubiquitination (Fujita et al. 2002).
Pizarro-Cerdá, J, Bonazzi, M, Veiga, E, Cossart, P
ubiquitin protein ligase activity of InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane]
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