CBLL1 ubiqutinates the InlA-bound CDH1 complex

Stable Identifier
R-HSA-8877003
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane, cell wall, cytosol
Synonyms
Hakai ubiqutinates InlA-bound E-cadherin complex
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CBLL1 ubiqutinates the InlA-bound CDH1 complex
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CBL-like E3 ubiquitin ligase Hakai (CBLL1) ubiquitinates the E-cadherin complex engaged by binding of E-cadherin (CDH1) to internalin (InlA), a cell wall protein of Listeria monocytogenes. CBLL1 ubiquitinates both CDH1 and CDH1-bound beta-catenin (CTNNB1), triggering endocytosis of the InlA-bound CDH1 complex and entry of bacteria to host cells. It appears that both clathrin-mediated and caveolin-mediated endocytosis contribute to invasion of host cells by Listeria monocytogenes via the InlA-CDH1 route (Bonazzi et al. 2008).
CBLL1 may undergo SRC-mediated phosphorylation and subsequent auto-ubiquitination (Fujita et al. 2002).

Literature References
PubMed ID Title Journal Year
18624796 Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes

Bonazzi, M, Veiga, E, Pizarro-Cerdá, J, Cossart, P

Cell. Microbiol. 2008
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane]
Physical Entity
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane]
Activity
ubiquitin protein ligase activity (0061630)
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Schwerk, C  (2016-10-25)
Created
Orlic-Milacic, M  (2016-06-17)