SRC phosphorylates InlA-bound CDH1 and CTNNB1

Stable Identifier
R-HSA-8876948
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
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SRC-mediated phosphorylation of E-cadherin (CDH1) is needed for InlA-mediated entry of Listeria monocytogenes into host cells (Bonazzi et al. 2008). At cell adhesion sites, SRC is known to phosphorylate CDH1 at tyrosine residues Y753 and Y754 and CDH1-bound beta-catenin (CTNNB1) at an unknown tyrosine residue. SRC-phosphorylated tyrosines of CDH1 and CTNNB1 serve as docking sites for the E3 ubiquitin ligase Hakai (CBLL1) (Fujita et al. 2002, Mukherjee et al. 2012).

Literature References
PubMed ID Title Journal Year
18624796 Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes

Bonazzi, M, Veiga, E, Pizarro-Cerdá, J, Cossart, P

Cell. Microbiol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Reviewed
Created