Reactome | CARNMT1 methylates CARN to Anserine

CARNMT1 methylates CARN to Anserine

Stable Identifier

R-HSA-8876789

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

carnosine + S-adenosyl-L-methionine => anserine + H(+) + S-adenosyl-L-homocysteine

ReviewStatus

5/5

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Anserine (Beta-alanyl-N(Pi)-methyl-L-histidine) is a methylated derivative of carnosine (Beta-alanyl-L-histidine) and an abundant constituent of vertebrate skeletal muscles (Boldyrev et al. 2013). It has been suggested to serve as a proton buffer and radical scavenger. The formation of anserine is catalyzed by carnosine N-methyltransferase (CARNMT1), which transfers a methyl group from S-adenosyl-L-methionine (SAM) onto the nitrogen atom (Pi) of L-histidine residue in carnosine (Drozak et al. 2015). While CARNMT1 produces anserine in mammals, a similar reaction is catalysed by a different enzyme (carnosine N-methyltransferase 2) in birds and reptiles (Drozak et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
26001783	UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase Drozak, J, Piecuch, M, Poleszak, O, Kozlowski, P, Chrobok, L, Baelde, HJ, de Heer, E	J. Biol. Chem.	2015