Reactome | RAB13 GEFs exchange GTP for GDP on RAB13

RAB13 GEFs exchange GTP for GDP on RAB13

Stable Identifier

R-HSA-8876615

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cell junction, cytosol

ReviewStatus

5/5

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RAB13 GEFs exchange GTP for GDP on RAB13

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RAB13 is involved in the trafficking of proteins in the biosynthetic and endosomal recycling pathways and contributes to processes such as tight junction formation and cell adhesion, GLUT 4 transport, angiogenesis, reorganization of the actin cytoskeleton, cell migration and cellular proliferation (Marzesco et al, 2002; Kohler et al, 2004; Morimoto et al, 2005; Terai et al, 2006; Yamamura et al, 2008; Nokes et al, 2008; Sun et al, 2010; Sakane et al, 2010; Sun et al, 2012; Nishikimi et al, 2014; Sun et al, 2016). These processes are often misregulated in cancer cells, and consistent with this, RAB13 has been implicated as a driver of cancer progression and is upregulated in multiple cancer types (Mahadevan et al, 2005; Li et al, 2014; Ioannou et al, 2015; reviewed in Iaonnou and McPherson, 2016). RAB13 is activated at the plasma membrane by its GEFs, DENND1C and DENND2B (also known as ST5), and may also be activated at other sites at lower levels (Yoshimura et al, 2010; Marat et al, 2012; Nishikimi et al, 2014; Ioannou et al, 2015; reviewed in Ishida et al, 2016). In this reaction, GDI and CHM proteins are depicted keeping the inactive, GDP-bound RAB13 soluble, in accordance with the classic view of the RAB cycle. A recent paper, however, provides evidence that in the case of RAB13, inactive RAB13:GDP traffics on vesicles, tethered by interaction with vesicle-bound proteins, and resists GDI-dependent extraction from membranes (Ioannou et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
20008558	Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2 Sakane, A, Honda, K, Sasaki, T	Mol. Cell. Biol.	2010
25713415	DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior Ioannou, MS, Bell, ES, Girard, M, Chaineau, M, Hamlin, JN, Daubaras, M, Monast, A, Park, M, Hodgson, L, McPherson, PS	J. Cell Biol.	2015
20937701	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors Yoshimura, S, Gerondopoulos, A, Linford, A, Rigden, DJ, Barr, FA	J. Cell Biol.	2010
18779367	Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells Nokes, RL, Fields, IC, Collins, RN, Fölsch, H	J. Cell Biol.	2008
22072793	Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton Marat, AL, Ioannou, MS, McPherson, PS	Mol. Biol. Cell	2012
21041651	Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells Sun, Y, Bilan, PJ, Liu, Z, Klip, A	Proc Natl Acad Sci U S A	2010
18094055	The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions Yamamura, R, Nishimura, N, Nakatsuji, H, Arase, S, Sasaki, T	Mol. Biol. Cell	2008
16525024	JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin Terai, T, Nishimura, N, Kanda, I, Yasui, N, Sasaki, T	Mol. Biol. Cell	2006
27044746	Regulation of Cancer Cell Behavior by the Small GTPase Rab13 Ioannou, MS, McPherson, PS	J. Biol. Chem.	2016
25074980	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking Nishikimi, A, Ishihara, S, Ozawa, M, Etoh, K, Fukuda, M, Kinashi, T, Katagiri, K	Sci Signal	2014
12058051	The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells Marzesco, AM, Dunia, I, Pandjaitan, R, Recouvreur, M, Dauzonne, D, Benedetti, EL, Louvard, D, Zahraoui, A	Mol. Biol. Cell	2002
15096524	Rab13 regulates PKA signaling during tight junction assembly Köhler, K, Louvard, D, Zahraoui, A	J. Cell Biol.	2004
25341920	Rab proteins and the compartmentalization of the endosomal system Wandinger-Ness, A, Zerial, M	Cold Spring Harb Perspect Biol	2014
24967941	Bioinformatics analysis reveals disturbance mechanism of MAPK signaling pathway and cell cycle in Glioblastoma multiforme Li, W, Li, K, Zhao, L, Zou, H	Gene	2014
15528189	Rab13 mediates the continuous endocytic recycling of occludin to the cell surface Morimoto, S, Nishimura, N, Terai, T, Manabe, S, Yamamoto, Y, Shinahara, W, Miyake, H, Tashiro, S, Shimada, M, Sasaki, T	J. Biol. Chem.	2005
16373702	Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures Mahadevan, D, Spier, C, Della Croce, K, Miller, S, George, B, Riley, C, Warner, S, Grogan, TM, Miller, TP	Mol. Cancer Ther.	2005
27246931	Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases Ishida, M, Oguchi, ME, Fukuda, M	Cell Struct. Funct.	2016
26538022	A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis Sun, Y, Jaldin-Fincati, J, Liu, Z, Bilan, PJ, Klip, A	Mol. Biol. Cell	2016