InlA binds CDH1

Stable Identifier
R-HSA-8876497
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
Synonyms
Internalin A binds E-cadherin
Locations in the PathwayBrowser
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Internalin (InlA), a cell wall protein of Listeria monocytogenes, binds to the E-cadherin (CDH1) complex at the plasma membrane of the host cell, triggering bacterial entry (Mengaud et al. 1996). The first extracellular domain (EC1) of CDH1 is involved in InlA binding, with proline residue P16 being critical for the interaction (Lecuit et al. 1999).

Literature References
PubMed ID Title Journal Year
8601315 E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells

Mengaud, J, Ohayon, H, Gounon, P, Mege R-M, R-M, Cossart, P

Cell 1996
10406800 A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes

Lecuit, M, Dramsi, S, Gottardi, C, Fedor-Chaiken, M, Gumbiner, B, Cossart, P

EMBO J. 1999
Participants
Participant Of
Disease
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Reviewed
Created