LDL translocates from endosome lumen to lysosome lumen

Stable Identifier
R-HSA-8876366
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
endosome lumen, lysosomal lumen
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LDL translocates from endosome lumen to lysosome lumen
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Once low-density lipoprotein (LDL) is freed from the LDLR to the endosomal lumen, it translocates to the lysosomal lumen for degradation via a receptor-mediated endocytotic mechanism (Goldstein et al. 1979).

Literature References
PubMed ID Title Journal Year
221835 Coated pits, coated vesicles, and receptor-mediated endocytosis

Goldstein, JL, Brown, MS, Anderson, RG

Nature 1979
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Authored
Jassal, B  (2016-06-14)
Reviewed
D'Eustachio, P  (2016-10-19)
Created
Jassal, B  (2016-06-14)
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