Reactome | SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol

SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol

Stable Identifier

R-HSA-8876312

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol

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The sodium-coupled monocarboxylate transporter 2 (SLC5A12, SMCT2) acts as a plasma membrane-bound electroneutral and low-affinity Na+-dependent sodium-coupled solute transporter. It is highly expressed in the kidney cortex and may be responsible for the first step of reabsorption of monocarboxylates from the proximal tubule lumen. Functional studies of SLC5A12 expressed in mammalian cells show it can mediate cotransport of Na+ with lactate, pyruvate and nicotinate (Gopal et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17692818	Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney Umapathy, NS, Ananth, S, Martin, PM, Ganapathy, V, Gnana-Prakasam, JP, Prasad, PD, Becker, H, Wagner, CA, Gopal, E	Biochim. Biophys. Acta	2007