SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol

Stable Identifier
R-HSA-8876312
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The sodium-coupled monocarboxylate transporter 2 (SLC5A12, SMCT2) acts as a plasma membrane-bound electroneutral and low-affinity Na+-dependent sodium-coupled solute transporter. It is highly expressed in the kidney cortex and may be responsible for the first step of reabsorption of monocarboxylates from the proximal tubule lumen. Functional studies of SLC5A12 expressed in mammalian cells show it can mediate cotransport of Na+ with lactate, pyruvate and nicotinate (Gopal et al. 2007).

Literature References
PubMed ID Title Journal Year
17692818 Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney

Gopal, E, Umapathy, NS, Martin, PM, Ananth, S, Gnana-Prakasam, JP, Becker, H, Wagner, CA, Ganapathy, V, Prasad, PD

Biochim. Biophys. Acta 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
organic acid:sodium symporter activity of SLC5A12 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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