The sodium-coupled monocarboxylate transporter 2 (SLC5A12, SMCT2) acts as a plasma membrane-bound electroneutral and low-affinity Na+-dependent sodium-coupled solute transporter. It is highly expressed in the kidney cortex and may be responsible for the first step of reabsorption of monocarboxylates from the proximal tubule lumen. Functional studies of SLC5A12 expressed in mammalian cells show it can mediate cotransport of Na+ with lactate, pyruvate and nicotinate (Gopal et al. 2007).
Umapathy, NS, Ananth, S, Martin, PM, Ganapathy, V, Gnana-Prakasam, JP, Prasad, PD, Becker, H, Wagner, CA, Gopal, E
organic acid:sodium symporter activity of SLC5A12 [plasma membrane]
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