Reactome | SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol

SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol

Stable Identifier

R-HSA-8876283

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol

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The sodium/glucose cotransporter 5 (SLC5A10, sodium glucose cotransporter 5, SGLT5) is a plasma membrane-bound transport protein that possesses high capacity to transport mannose (Man) and fructose (Fru) into cells (Grempler et al. 2012). SLC5A10 is exclusively expressed in the kidney and is also able to transport glucose, alpha-methyl-D-glucose (AMG) and galactose, although to a much lower extent than Man and Fru.

Literature References

PubMed ID	Title	Journal	Year
22212718	Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter Grempler, R, Augustin, R, Froehner, S, Hildebrandt, T, Simon, E, Mark, M, Eickelmann, P	FEBS Lett.	2012