EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB

Stable Identifier
R-HSA-8876262
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane, peptidoglycan-based cell wall, cytosol
ReviewStatus
5/5
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EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB
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Proteins involved in clathrin-mediated endocytosis EPS15 and HGS (Hrs) are both necessary for CBL and MET-mediated entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005). Based on the analogy with HGF-activated MET signaling (Bache et al. 2003, Row et al. 2005, Parachoniak et al. 2009), HGS and EPS15, in complex with STAM proteins, bind to MET receptor monoubiquitinated by CBL upon MET receptor activation by the Listeria monocytogenes InlB protein.
Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells

Veiga, E, Cossart, P

Nat. Cell Biol. 2005
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Output
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Inferred From
EPS15 and HGS bind ubiquitinated MET (Homo sapiens)
Disease
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Schwerk, C  (2016-10-25)
Created
Orlic-Milacic, M  (2016-06-11)
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