MET bound to Listeria monocytogenes InlB protein undergoes trans-autophosphorylation. Phosphorylation at tyrosine residues Y1234 and Y1235 in the activation loop of the kinase domain of MET was specifically demonstrated. As InlB-activated MET activates downstream signaling by ERKs (MAPKs) and PI3K/AKT, MET is presumably phosphorylated on GRB2 and GAB1 docking sites Y1349 and Y1356, respectively (Niemann et al. 2007, Ferraris et al. 2010).
van den Heuvel, J,