Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GGC-RAB8A [trans-Golgi network membrane]
Stable Identifier
R-HSA-8876082
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
RAB8 GEFs exchange GTP for GDP on RAB8 (Homo sapiens)
GGC-RAB8:GTP [trans-Golgi network membrane] (Homo sapiens)
GGC-RAB8 [trans-Golgi network membrane] (Homo sapiens)
GGC-RAB8A [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61006 RAB8A
Gene Names
RAB8A, MEL, RAB8
Chain
chain:1-204, propeptide:205-207
Reference Genes
BioGPS Gene:4218 RAB8A
COSMIC (genes):RAB8A RAB8A
CTD Gene:4218 RAB8A
dbSNP Gene:4218 RAB8A
ENSEMBL:ENSG00000167461 RAB8A
HGNC:7007 RAB8A
KEGG:hsa:4218 RAB8A
Monarch:4218 RAB8A
NCBI Gene:4218 RAB8A
OMIM:165040 RAB8A
UCSC:P61006 RAB8A
Reference Transcript
RefSeq:NM_005370.4 RAB8A
Other Identifiers
11742706_s_at
16859270
208819_PM_at
208819_at
35339_at
35340_at
3823555
3823556
3823557
3823558
3823559
3823560
3823561
3823563
3823564
3823567
3823568
3823569
3823570
3823575
3823576
3823577
3823578
3823579
3823580
3823582
4218
43190_at
8026520
A_14_P111306
A_23_P164752
A_24_P190424
A_33_P3320127
GE62175
GO:0000139
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005768
GO:0005794
GO:0005813
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0006886
GO:0006887
GO:0006904
GO:0006914
GO:0007030
GO:0007409
GO:0008021
GO:0008092
GO:0009306
GO:0010008
GO:0010506
GO:0015031
GO:0016192
GO:0016787
GO:0019003
GO:0019901
GO:0030030
GO:0030140
GO:0030425
GO:0030496
GO:0030670
GO:0031267
GO:0031410
GO:0031489
GO:0032456
GO:0032588
GO:0032869
GO:0032880
GO:0036064
GO:0043005
GO:0043025
GO:0043197
GO:0043226
GO:0044782
GO:0045202
GO:0045335
GO:0048169
GO:0048210
GO:0051223
GO:0055037
GO:0055038
GO:0060170
GO:0060271
GO:0061024
GO:0061512
GO:0070062
GO:0072659
GO:0097546
GO:0097730
GO:0098887
GO:0098969
GO:0098978
GO:0099003
GO:1990782
HMNXSV003049034
ILMN_1760858
PH_hs_0000602
TC19000317.hg
TC19002017.hg
X56741_at
g12804236_3p_at
Participates
as a member of
GGC-RAB8 [trans-Golgi network membrane] (Homo sapiens)
Other forms of this molecule
RAB8A [Golgi membrane]
RAB8A [cytosol]
GGC-RAB8A [cytosol]
RAB8A [recycling endosome membrane]
GGC-RAB8A [cytoplasmic vesicle membrane]
Inferred To
Homologues of GGC-RAB8A [trans-Golgi network membrane]
(Caenorhabditis elegans)
Homologues of GGC-RAB8A [trans-Golgi network membrane]
(Dictyostelium discoideum)
Homologues of GGC-RAB8A [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
Rab8 [trans-Golgi network membrane]
(Drosophila melanogaster)
rabr-1 [trans-Golgi network membrane]
(Caenorhabditis elegans)
GGC-RAB8A [trans-Golgi network membrane]
(Bos taurus)
GGC-RAB8A [trans-Golgi network membrane]
(Canis familiaris)
GGC-RAB8A [trans-Golgi network membrane]
(Dictyostelium discoideum)
GGC-RAB8A [trans-Golgi network membrane]
(Gallus gallus)
GGC-RAB8A [trans-Golgi network membrane]
(Mus musculus)
GGC-RAB8A [trans-Golgi network membrane]
(Rattus norvegicus)
GGC-RAB8A [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
GGC-RAB8A [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
rab8a [trans-Golgi network membrane]
(Danio rerio)
rab8a [trans-Golgi network membrane]
(Xenopus tropicalis)
RAB8A [trans-Golgi network membrane]
(Sus scrofa)
rab-8 [trans-Golgi network membrane]
(Caenorhabditis elegans)
Modified Residues
Name
S-geranylgeranyl-L-cysteine at 204
Coordinate
204
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Cross References
RefSeq
NP_005361.2
OpenTargets
ENSG00000167461
ENSEMBL
ENST00000586682
,
ENSP00000300935
,
ENST00000300935
,
ENSP00000467501
IntEnz
3.6.5.2
HPA
ENSG00000167461-RAB8A
PRO
P61006
Pharos - Targets
P61006
GlyGen
P61006
PDB
6STG
,
3QBT
,
4LHZ
,
7BWT
,
3TNF
,
4LHW
,
5SZI
,
6RIR
,
4LHV
,
7LWB
,
4LHY
,
4LHX
,
6YX5
,
6WHE
,
6SQ2
,
4LI0
,
6STF
,
6ZSI
,
6ZSJ
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
GDP [ChEBI:17552]
7
GDP [lysosomal membrane]
(R-ALL-9628545)
GDP [cytoplasmic vesicle membrane]
(R-ALL-1996292)
GDP [cilium]
(R-ALL-5617810)
GDP [platelet dense granule lumen]
(R-ALL-114622)
GDP [nucleoplasm]
(R-ALL-111349)
GDP [plasma membrane]
(R-ALL-114549)
GDP [endoplasmic reticulum lumen]
(R-ALL-1467290)
0.819
24
UniProt:Q96QF0 RAB3IP
1
RAB3IP [cytosol]
(R-HSA-5617610)
0.781
6
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.77
9
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.676
3
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.633
4
UniProt:O60271 SPAG9
1
SPAG9 [cytosol]
(R-HSA-375975)
0.623
3
UniProt:Q9Y5M8 SRPRB
1
SRPRB [endoplasmic reticulum membrane]
(R-HSA-265002)
0.527
2
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.508
2
UniProt:Q8TAG9 EXOC6
2
EXOC6 [plasma membrane]
(R-HSA-265041)
EXOC6 [cytosol]
(R-HSA-5623384)
0.508
2
UniProt:Q8NFJ9 BBS1
1
BBS1 [cytosol]
(R-HSA-5617640)
0.508
2
UniProt:Q9NX63 CHCHD3
3
CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874907)
4xHC-CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874910)
CHCHD3 (MIC19) [mitochondrial inner membrane]
(R-HSA-8949583)
0.508
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text