SLC45A3 transports Glc from extracellular region to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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Maintenance of myelin structure and function requires appropriate lipids and myelin-specific proteins, all controlled in a tight fashion. Myelin is generated by the extension of oligodendrocyte cell membranes. Damaged myelin is implicated in many demyelinating neurological disorders such as multiple sclerosis, leukodystrophies and demyelinating neuropathies. The micro-RNA miR-32 is highly expressed in the myelin-enriched regions of the brain and mature oligodendrocytes, and it promotes myelin protein expression. It can directly regulate the expression of solute carrier family 45 member 3 (SLC45A3, prostein), a prostate-specific protein expressed in normal and malignant prostate tissues (Xu et al. 2001, Kiessling et al. 2004). SLC45A3 is suggested to be a myelin-enriched putative sugar transporter and therefore, indirectly, involved in fatty acid sythesis in oligodendrocytes (Shin et al. 2012).
Literature References
PubMed ID Title Journal Year
14997204 Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein

Schmitz, M, Rieger, MA, Kiessling, A, Weigle, B, Temme, A, Stevanovic, S, Rieber, EP, Füssel, S

Br. J. Cancer 2004
22521588 miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin

Fu, YH, Ptáček, LJ, Shin, D, Howng, SY

Neuroscience 2012
11245466 Identification and characterization of prostein, a novel prostate-specific protein

Filho, AM, Nolasco, M, Badaró, R, Houghton, RL, Zhang, X, Kalos, M, Xu, J, Reed, SG, Zasloff, EJ, Stolk, JA

Cancer Res. 2001
Catalyst Activity

sugar transmembrane transporter activity of SLC45A3 [plasma membrane]

This event is regulated
Positively by
Orthologous Events
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