Reactome | SLC45A3 transports Glc from extracellular region to cytosol

SLC45A3 transports Glc from extracellular region to cytosol

Stable Identifier

R-HSA-8875902

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SLC45A3 transports Glc from extracellular region to cytosol

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Maintenance of myelin structure and function requires appropriate lipids and myelin-specific proteins, all controlled in a tight fashion. Myelin is generated by the extension of oligodendrocyte cell membranes. Damaged myelin is implicated in many demyelinating neurological disorders such as multiple sclerosis, leukodystrophies and demyelinating neuropathies. The micro-RNA miR-32 is highly expressed in the myelin-enriched regions of the brain and mature oligodendrocytes, and it promotes myelin protein expression. It can directly regulate the expression of solute carrier family 45 member 3 (SLC45A3, prostein), a prostate-specific protein expressed in normal and malignant prostate tissues (Xu et al. 2001, Kiessling et al. 2004). SLC45A3 is suggested to be a myelin-enriched putative sugar transporter and therefore, indirectly, involved in fatty acid sythesis in oligodendrocytes (Shin et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
14997204	Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein Schmitz, M, Rieger, MA, Kiessling, A, Weigle, B, Temme, A, Stevanovic, S, Rieber, EP, Füssel, S	Br. J. Cancer	2004
22521588	miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin Fu, YH, Ptáček, LJ, Shin, D, Howng, SY	Neuroscience	2012
11245466	Identification and characterization of prostein, a novel prostate-specific protein Filho, AM, Nolasco, M, Badaró, R, Houghton, RL, Zhang, X, Kalos, M, Xu, J, Reed, SG, Zasloff, EJ, Stolk, JA	Cancer Res.	2001