Reactome | MET promotes cell motility

MET promotes cell motility

Stable Identifier

R-HSA-8875878

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Direct and indirect interactions of MET with integrins, focal adhesion kinase PTK2 (FAK1), tensin-4 (TNS4) and GTPases RAP1 and RAC1, induce morphological changes that promote cell motility and play an important role in HGF-induced invasiveness of cancer cells (Weidner et al. 1993, Beviglia et al. 1999, Sakkab et al. 2000, Parr et al. 2001, Trusolino et al. 2001, Lamorte et al. 2002, Chen and Chen 2006, Watanabe et al. 2006, Muharram et al. 2014, Murray et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
10521801	HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells Beviglia, L, Kramer, RH	Int. J. Cancer	1999
8384622	The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells Weidner, KM, Sachs, M, Birchmeier, W	J. Cell Biol.	1993
11478803	The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant Parr, C, Davies, G, Nakamura, T, Matsumoto, K, Mason, MD, Jiang, WG	Biochem. Biophys. Res. Commun.	2001
24518591	Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation Murray, DW, Didier, S, Chan, A, Paulino, V, van Aelst, L, Ruggieri, R, Tran, NL, Byrne, AT, Symons, M	Br. J. Cancer	2014
24814316	Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells Muharram, G, Sahgal, P, Korpela, T, De Franceschi, N, Kaukonen, R, Clark, K, Tulasne, D, Carpén, O, Ivaska, J	Dev. Cell	2014
16849525	Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines Watanabe, T, Tsuda, M, Makino, Y, Ichihara, S, Sawa, H, Minami, A, Mochizuki, N, Nagashima, K, Tanaka, S	Mol. Cancer Res.	2006
10753869	Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL Sakkab, D, Lewitzky, M, Posern, G, Schaeper, U, Sachs, M, Birchmeier, W, Feller, SM	J. Biol. Chem.	2000
16782899	Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion Chen, SY, Chen, HC	Mol. Cell. Biol.	2006
12006644	Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions Lamorte, L, Royal, I, Naujokas, M, Park, M	Mol. Biol. Cell	2002