Reactome | MET phosphorylates STAT3

MET phosphorylates STAT3

Stable Identifier

R-HSA-8875817

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Activated MET phosphorylates STAT3 at Y705, triggering STAT3 dimerization and nuclear translocation (Boccaccio et al. 1998, Zhang et al. 2002, Cramer et al. 2005). Endocytosis of MET and interaction with STAT3 at endosomes may be required for sustained STAT3 phosphorylation in response to HGF stimulation (Kermorgant and Parker 2008). Activated SRC may also contribute to phosphorylation of STAT3 at Y705. STAT3 may promote HGF transcription in a SRC-dependent way, but this autocrine HGF loop may be limited to breast cancer cells (Wojcik et al. 2006, Sam et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
18779368	Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation Kermorgant, S, Parker, PJ	J. Cell Biol.	2008
15838885	Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3 Friedrich, K, Westermann, M, Meissner, A, Lange, A, Kleiner, S, Cramer, A	J. Cell. Biochem.	2005
9440692	Induction of epithelial tubules by growth factor HGF depends on the STAT pathway Bardelli, A, Comoglio, PM, Battistini, C, Tamagnone, L, Boccaccio, C, Andò, M, Michieli, P	Nature	1998
11803465	Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis Jove, R, Zhang, YW, Vande Woude, GF, Wang, LM	Oncogene	2002
16407846	A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells Wright, TG, Sharifpoor, S, Miller, NA, Swan, K, Watering, R, Tremblay, EA, Wojcik, EJ, Mueller, CR, Elliott, BE	Oncogene	2006
17967179	A novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells Elliott, BE, Sam, MR, Mueller, CR	Mol. Cancer	2007