MET phosphorylates STAT3

Stable Identifier
R-HSA-8875817
Type
Reaction [transition]
Species
Homo sapiens
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Activated MET phosphorylates STAT3 at Y705, triggering STAT3 dimerization and nuclear translocation (Boccaccio et al. 1998, Zhang et al. 2002, Cramer et al. 2005). Endocytosis of MET and interaction with STAT3 at endosomes may be required for sustained STAT3 phosphorylation in response to HGF stimulation (Kermorgant and Parker 2008). Activated SRC may also contribute to phosphorylation of STAT3 at Y705. STAT3 may promote HGF transcription in a SRC-dependent way, but this autocrine HGF loop may be limited to breast cancer cells (Wojcik et al. 2006, Sam et al. 2007).

Literature References
PubMed ID Title Journal Year
15838885 Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3

Cramer, A, Kleiner, S, Westermann, M, Meissner, A, Lange, A, Friedrich, K

J. Cell. Biochem. 2005
18779368 Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation

Kermorgant, S, Parker, PJ

J. Cell Biol. 2008
9440692 Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

Boccaccio, C, Andò, M, Tamagnone, L, Bardelli, A, Michieli, P, Battistini, C, Comoglio, PM

Nature 1998
11803465 Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

Zhang, YW, Wang, LM, Jove, R, Vande Woude, GF

Oncogene 2002
16407846 A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells

Wojcik, EJ, Sharifpoor, S, Miller, NA, Wright, TG, Watering, R, Tremblay, EA, Swan, K, Mueller, CR, Elliott, BE

Oncogene 2006
17967179 A novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells

Sam, MR, Elliott, BE, Mueller, CR

Mol. Cancer 2007
Participants
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Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of HGF:p-4Y-MET dimer:STAT3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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