STAT3 binds activated MET receptor

Stable Identifier
R-HSA-8875816
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The STAT3 transcription factor may bind, directly and indirectly, to activated MET. Direct binding of STAT3 involves phosphorylated tyrosine residue Y1356 of MET. Indirect binding of STAT3 to activated MET involves GAB1, but this interaction has not been studied in detail (Schaper et al. 1997, Boccaccio et al. 1998).

Literature References
PubMed ID Title Journal Year
9094433 Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

Schaper, F, Siewert, E, Gómez-Lechon, MJ, Gatsios, P, Sachs, M, Birchmeier, W, Heinrich, PC, Castell, J

FEBS Lett. 1997
9440692 Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

Boccaccio, C, Andň, M, Tamagnone, L, Bardelli, A, Michieli, P, Battistini, C, Comoglio, PM

Nature 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed