Reactome | STAT3 binds activated MET receptor

STAT3 binds activated MET receptor

Stable Identifier

R-HSA-8875816

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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The STAT3 transcription factor may bind, directly and indirectly, to activated MET. Direct binding of STAT3 involves phosphorylated tyrosine residue Y1356 of MET. Indirect binding of STAT3 to activated MET involves GAB1, but this interaction has not been studied in detail (Schaper et al. 1997, Boccaccio et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9094433	Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes Schaper, F, Siewert, E, Gómez-Lechon, MJ, Gatsios, P, Sachs, M, Birchmeier, W, Heinrich, PC, Castell, J	FEBS Lett.	1997
9440692	Induction of epithelial tubules by growth factor HGF depends on the STAT pathway Boccaccio, C, Andò, M, Tamagnone, L, Bardelli, A, Michieli, P, Battistini, C, Comoglio, PM	Nature	1998