Reactome | CRK,CRKL recruits RAC1 GEF to activated MET

CRK,CRKL recruits RAC1 GEF to activated MET

Stable Identifier

R-HSA-8875576

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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CRK,CRKL recruits RAC1 GEF to activated MET

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Recruitment of CRK or related CRKL to MET-phosphorylated GAB1 results in increased level of activated RAC1 (RAC1:GTP), a necessary step in HGF-induced cell motility (Lamorte et al. 2002, Watanabe et al. 2006). DOCK7 was recently implicated as a RAC1 guanyl nucleotide exchange factor (GEF) recruited to activated MET receptor via GAB1. Binding of DOCK7 to GAB1-bound CRK or CRKL was proposed but has not been examined (Murray et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24518591	Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation Murray, DW, Didier, S, Chan, A, Paulino, V, van Aelst, L, Ruggieri, R, Tran, NL, Byrne, AT, Symons, M	Br. J. Cancer	2014
16849525	Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines Watanabe, T, Tsuda, M, Makino, Y, Ichihara, S, Sawa, H, Minami, A, Mochizuki, N, Nagashima, K, Tanaka, S	Mol. Cancer Res.	2006
12006644	Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions Lamorte, L, Royal, I, Naujokas, M, Park, M	Mol. Biol. Cell	2002