CRK,CRKL recruits RAC1 GEF to activated MET

Stable Identifier
Reaction [uncertain]
Homo sapiens
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Recruitment of CRK or related CRKL to MET-phosphorylated GAB1 results in increased level of activated RAC1 (RAC1:GTP), a necessary step in HGF-induced cell motility (Lamorte et al. 2002, Watanabe et al. 2006). DOCK7 was recently implicated as a RAC1 guanyl nucleotide exchange factor (GEF) recruited to activated MET receptor via GAB1. Binding of DOCK7 to GAB1-bound CRK or CRKL was proposed but has not been examined (Murray et al. 2014).

Literature References
PubMed ID Title Journal Year
24518591 Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

van Aelst, L, Didier, S, Byrne, AT, Murray, DW, Paulino, V, Ruggieri, R, Tran, NL, Chan, A, Symons, M

Br. J. Cancer 2014
16849525 Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines

Tanaka, S, Makino, Y, Ichihara, S, Tsuda, M, Watanabe, T, Mochizuki, N, Minami, A, Sawa, H, Nagashima, K

Mol. Cancer Res. 2006
12006644 Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions

Lamorte, L, Naujokas, M, Park, M, Royal, I

Mol. Biol. Cell 2002
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