Recruitment of CRK or related CRKL to MET-phosphorylated GAB1 results in increased level of activated RAC1 (RAC1:GTP), a necessary step in HGF-induced cell motility (Lamorte et al. 2002, Watanabe et al. 2006). DOCK7 was recently implicated as a RAC1 guanyl nucleotide exchange factor (GEF) recruited to activated MET receptor via GAB1. Binding of DOCK7 to GAB1-bound CRK or CRKL was proposed but has not been examined (Murray et al. 2014).
van Aelst, L, Didier, S, Byrne, AT, Murray, DW, Paulino, V, Ruggieri, R, Tran, NL, Chan, A, Symons, M
Tanaka, S, Makino, Y, Ichihara, S, Tsuda, M, Watanabe, T, Mochizuki, N, Minami, A, Sawa, H, Nagashima, K
Lamorte, L, Naujokas, M, Park, M, Royal, I
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