CRK,CRKL recruits RAC1 GEF to activated MET

Stable Identifier
R-HSA-8875576
Type
Reaction [uncertain]
Species
Homo sapiens
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Recruitment of CRK or related CRKL to MET-phosphorylated GAB1 results in increased level of activated RAC1 (RAC1:GTP), a necessary step in HGF-induced cell motility (Lamorte et al. 2002, Watanabe et al. 2006). DOCK7 was recently implicated as a RAC1 guanyl nucleotide exchange factor (GEF) recruited to activated MET receptor via GAB1. Binding of DOCK7 to GAB1-bound CRK or CRKL was proposed but has not been examined (Murray et al. 2014).

Literature References
PubMed ID Title Journal Year
16849525 Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines

Watanabe, T, Tsuda, M, Makino, Y, Ichihara, S, Sawa, H, Minami, A, Mochizuki, N, Nagashima, K, Tanaka, S

Mol. Cancer Res. 2006
24518591 Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

Murray, DW, Didier, S, Chan, A, Paulino, V, van Aelst, L, Ruggieri, R, Tran, NL, Byrne, AT, Symons, M

Br. J. Cancer 2014
12006644 Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions

Lamorte, L, Royal, I, Naujokas, M, Park, M

Mol. Biol. Cell 2002
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