Reactome | InlB binds MET

InlB binds MET

Stable Identifier

R-HSA-8875371

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Listeria monocytogenes

Compartment

cell wall, plasma membrane

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InlB, a cell wall protein of Listeria monocytogenes, binds MET receptor, acting as an HGF agonist. InlB interacts with the extracellular portion of MET via two interfaces: the leucine rich repeat region (LRR) of InlB interacts with the Ig1 repeat of MET, while the inter-repeat (IR) region of InlB interacts with the Sema domain of MET (Shen et al. 2000, Veiga and Cossart 2005, Niemann et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
16113677	Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells Veiga, E, Cossart, P	Nat. Cell Biol.	2005
11081636	InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase Shen, Y, Naujokas, M, Park, M, Ireton, K	Cell	2000
17662939	Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB Niemann, HH, Jäger, V, Butler, PJ, van den Heuvel, J, Schmidt, S, Ferraris, D, Gherardi, E, Heinz, DW	Cell	2007