InlB binds MET

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Listeria monocytogenes
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

InlB, a cell wall protein of Listeria monocytogenes, binds MET receptor, acting as an HGF agonist. InlB interacts with the extracellular portion of MET via two interfaces: the leucine rich repeat region (LRR) of InlB interacts with the Ig1 repeat of MET, while the inter-repeat (IR) region of InlB interacts with the Sema domain of MET (Shen et al. 2000, Veiga and Cossart 2005, Niemann et al. 2007).

Literature References
PubMed ID Title Journal Year
11081636 InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase

Park, M, Naujokas, M, Ireton, K, Shen, Y

Cell 2000
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells

Veiga, E, Cossart, P

Nat. Cell Biol. 2005
17662939 Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB

Heinz, DW, Ferraris, D, Schmidt, S, Gherardi, E, van den Heuvel, J, J├Ąger, V, Butler, PJ, Niemann, HH

Cell 2007
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Cite Us!