Reactome | RAB5 GEFs exchange GTP for GDP on RAB5

RAB5 GEFs exchange GTP for GDP on RAB5

Stable Identifier

R-HSA-8875320

Type

Reaction [transition]

Species

Homo sapiens

Compartment

early endosome membrane, cytosol

ReviewStatus

5/5

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RAB5 has roles at early endosomal compartments including fusion of vesicles originating from the plasma membrane with early endosomes, and is implicated in clathrin-mediated endocytosis (Chavrier et al, 1990; Bucci et al, 1992; Gorvel et al, 1991; Hoffenberg et al, 2000; Zeigerer et al, 2012; Taylor et al, 2011). RAB5 activation is mediated by a number of GEFs including members of the RIN (RAS and RAB interactor) and ALS2 families and GAPVD1, all of which belong to the VPS9-domain containing group (Horiuchi et al, 1997; Tall et al, 2001; Saito et al, 2002; Kajiho et al, 2003; Kajiho et al, 2011; Kunita et al, 2004; Hadano et al, 2004; Hunker et al, 2006; Suzuki-Utsunomiya et al, 2007; reviewed in Ishida et al, 2016). Interaction of RAB5 with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB5 with GDI and CHM proteins.

Literature References

PubMed ID	Title	Journal	Year
9323142	A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function Horiuchi, H, Lippé, R, McBride, HM, Rubino, M, Woodman, P, Stenmark, H, Rybin, V, Wilm, M, Ashman, K, Mann, M, Zerial, M	Cell	1997
12972505	RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway Kajiho, H, Saito, K, Tsujita, K, Kontani, K, Araki, Y, Kurosu, H, Katada, T	J. Cell. Sci.	2003
12427552	Molecular cloning and characterization of prokineticin receptors Soga, T, Matsumoto, S, Oda, T, Saito, T, Hiyama, H, Takasaki, J, Kamohara, M, Ohishi, T, Matsushime, H, Furuichi, K	Biochim Biophys Acta	2002
10818110	A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion Hoffenberg, S, Liu, X, Nikolova, L, Hall, HS, Dai, W, Baughn, RE, Dickey, BF, Barbieri, MA, Aballay, A, Stahl, PD, Knoll, BJ	J. Biol. Chem.	2000
2115402	Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments Chavrier, P, Parton, RG, Hauri, HP, Simons, K, Zerial, M	Cell	1990
21586568	Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31 Kajiho, H, Sakurai, K, Minoda, T, Yoshikawa, M, Nakagawa, S, Fukushima, S, Kontani, K, Katada, T	J. Biol. Chem.	2011
1900457	rab5 controls early endosome fusion in vitro Gorvel, JP, Chavrier, P, Zerial, M, Gruenberg, J	Cell	1991
17239822	ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics Suzuki-Utsunomiya, K, Hadano, S, Otomo, A, Kunita, R, Mizumura, H, Osuga, H, Ikeda, JE	Biochem. Biophys. Res. Commun.	2007
1516130	The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway Bucci, C, Parton, RG, Mather, IH, Stunnenberg, H, Simons, K, Hoflack, B, Zerial, M	Cell	1992
15247254	Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking Kunita, R, Otomo, A, Mizumura, H, Suzuki, K, Showguchi-Miyata, J, Yanagisawa, Y, Hadano, S, Ikeda, JE	J. Biol. Chem.	2004
11703925	Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1 Tall, GG, Barbieri, MA, Stahl, PD, Horazdovsky, BF	Dev. Cell	2001
15388334	ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics Hadano, S, Otomo, A, Suzuki-Utsunomiya, K, Kunita, R, Yanagisawa, Y, Showguchi-Miyata, J, Mizumura, H, Ikeda, JE	FEBS Lett.	2004
25341920	Rab proteins and the compartmentalization of the endosomal system Wandinger-Ness, A, Zerial, M	Cold Spring Harb Perspect Biol	2014
21445324	A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis Taylor, MJ, Perrais, D, Merrifield, CJ	PLoS Biol.	2011
16410077	Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis Hunker, CM, Galvis, A, Kruk, I, Giambini, H, Veisaga, ML, Barbieri, MA	Biochem. Biophys. Res. Commun.	2006
22622570	Rab5 is necessary for the biogenesis of the endolysosomal system in vivo Zeigerer, A, Gilleron, J, Bogorad, RL, Marsico, G, Nonaka, H, Seifert, S, Epstein-Barash, H, Kuchimanchi, S, Peng, CG, Ruda, VM, Del Conte-Zerial, P, Hengstler, JG, Kalaidzidis, Y, Koteliansky, V, Zerial, M	Nature	2012
27246931	Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases Ishida, M, Oguchi, ME, Fukuda, M	Cell Struct. Funct.	2016