RAB3 GEFs exchange GTP for GDP on RAB3A

Stable Identifier
R-HSA-8875318
Type
Reaction [transition]
Species
Homo sapiens
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RAB3A is involved in neurotransmitter release at the synaptic vesicle (Fischer et al, 1991; Holz et al, 1994; Geppert et al, 1994; Kapfhamer et al, 2002; reviewed in Pavlos and Jahn, 2011). RAB3A is activated at the synaptic vesicle through the guanine nucleotide exchange activity of RAB3IL1 (also known as GRAB) which promotes the exchange of GDP for GTP (Luo et al, 2001; Yoshimura et al, 2010). RAB3 family members are also activated by the DENN domain-containing GEF MADD, also known as RAB3GEP (Wada et al, 1997; Fukui et al, 1997; Iwasaki et al, 1997; Mahoney et al, 2006). Interaction of RAB3A with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB3A with GDI and CHM proteins.

Literature References
PubMed ID Title Journal Year
9020086 Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins

Wada, M, Nakanishi, H, Satoh, A, Hirano, H, Obaishi, H, Matsuura, Y, Takai, Y

J. Biol. Chem. 1997
9136770 aex-3 encodes a novel regulator of presynaptic activity in C. elegans

Iwasaki, K, Staunton, J, Saifee, O, Nonet, M, Thomas, JH

Neuron 1997
11516400 GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase

Luo, HR, Saiardi, A, Nagata, E, Ye, K, Yu, H, Jung, TS, Luo, X, Jain, S, Sawa, A, Snyder, SH

Neuron 2001
21776405 Distinct yet overlapping roles of Rab GTPases on synaptic vesicles

Pavlos, NJ, Jahn, R

Small GTPases 2011
8144603 Evidence for the involvement of Rab3A in Ca(2+)-dependent exocytosis from adrenal chromaffin cells

Holz, RW, Brondyk, WH, Senter, RA, Kuizon, L, Macara, IG

J. Biol. Chem. 1994
20937701 Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

Yoshimura, S, Gerondopoulos, A, Linford, A, Rigden, DJ, Barr, FA

J. Cell Biol. 2010
16571673 Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans

Mahoney, TR, Liu, Q, Itoh, T, Luo, S, Hadwiger, G, Vincent, R, Wang, ZW, Fukuda, M, Nonet, ML

Mol. Biol. Cell 2006
7911226 The role of Rab3A in neurotransmitter release

Geppert, M, Bolshakov, VY, Siegelbaum, SA, Takei, K, De Camilli, P, Hammer, RE, Südhof, TC

Nature 1994
25341920 Rab proteins and the compartmentalization of the endosomal system

Wandinger-Ness, A, Zerial, M

Cold Spring Harb Perspect Biol 2014
1845915 A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

Fischer von Mollard, G, Südhof, TC, Jahn, R

Nature 1991
12244319 Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse

Kapfhamer, D, Valladares, O, Sun, Y, Nolan, PM, Rux, JJ, Arnold, SE, Veasey, SC, Bućan, M

Nat. Genet. 2002
27246931 Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases

Ishida, M, Oguchi, ME, Fukuda, M

Cell Struct. Funct. 2016
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guanyl-nucleotide exchange factor activity of RAB3 GEFs [cytosol]

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