Reactome | CBL monoubiquitinates activated MET

CBL monoubiquitinates activated MET

Stable Identifier

R-HSA-8875183

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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CBL monoubiquitinates activated MET receptor probably at multiple lysine residues, triggering MET endocytosis and degradation through the lysosomal route (Abella et al. 2005, Veiga and Cossart 2005). InlB, a cell wall protein of Listeria monocytogenes, binds to MET receptor as an HGF agonist. The subsequent CBL-mediated monoubiquitination of MET promotes endocytosis of bacteria and entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).

Literature References

PubMed ID	Title	Journal	Year
16227611	Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation Abella, JV, Peschard, P, Naujokas, MA, Lin, T, Saucier, C, Urbé, S, Park, M	Mol. Cell. Biol.	2005
16113677	Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells Veiga, E, Cossart, P	Nat. Cell Biol.	2005