Reactome | CBL monoubiquitinates activated MET

CBL monoubiquitinates activated MET

Stable Identifier

R-HSA-8875183

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CBL monoubiquitinates activated MET receptor probably at multiple lysine residues, triggering MET endocytosis and degradation through the lysosomal route (Abella et al. 2005, Veiga and Cossart 2005). InlB, a cell wall protein of Listeria monocytogenes, binds to MET receptor as an HGF agonist. The subsequent CBL-mediated monoubiquitination of MET promotes endocytosis of bacteria and entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).

Literature References

PubMed ID	Title	Journal	Year
16113677	Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells Veiga, E, Cossart, P	Nat. Cell Biol.	2005
16227611	Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation Abella, JV, Peschard, P, Naujokas, MA, Lin, T, Saucier, C, Urbé, S, Park, M	Mol. Cell. Biol.	2005