CBL monoubiquitinates activated MET receptor probably at multiple lysine residues, triggering MET endocytosis and degradation through the lysosomal route (Abella et al. 2005, Veiga and Cossart 2005). InlB, a cell wall protein of Listeria monocytogenes, binds to MET receptor as an HGF agonist. The subsequent CBL-mediated monoubiquitination of MET promotes endocytosis of bacteria and entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).
Abella, JV, Peschard, P, Naujokas, MA, Lin, T, Saucier, C, Urbé, S, Park, M
Veiga, E, Cossart, P
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