EGFR gene expression is stimulated by TFAP2C

Stable Identifier
R-HSA-8874797
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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EGFR gene expression is stimulated by TFAP2C
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Binding of TFAP2C homodimers to the EGFR gene promoter region stimulates EGFR transcription and may play an important role in the etiology of luminal breast cancer (Park et al. 2015, de Andrade et al. 2016).
Literature References
PubMed ID Title Journal Year
26832794 EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib

De Andrade, JP, Park, JM, Gu, VW, Woodfield, GW, Kulak, MV, Lorenzen, AW, Wu, VT, Van Dorin, SE, Spanheimer, PM, Weigel, RJ

Mol. Cancer Ther. 2016
25772240 The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis

Park, JM, Wu, T, Cyr, AR, Woodfield, GW, De Andrade, JP, Spanheimer, PM, Li, T, Sugg, SL, Lal, G, Domann, FE, Zhang, W, Weigel, RJ

Oncogene 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TFAP2C homodimer:EGFR gene [nucleoplasm] (Homo sapiens)
Active Unit
TFAP2C homodimer [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Bogachek, MV  (2016-05-17)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-05-27)
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