Reactome | TTPA binds alpha-TOH

TTPA binds alpha-TOH

Stable Identifier

R-HSA-8874718

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, lysosomal membrane

ReviewStatus

5/5

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Alpha-tocopherol (alpha-TOH) belongs to the fat-soluble vitamin E family and is the major form used by humans as an important antioxidant of plasma lipoproteins and cell membranes. It is secreted from the liver into the blood stream but as it is a lipophilic compound, it requires intracellular binding proteins to bind and transport it to exert its actions. One such protein is alpha-tocopherol transfer protein (TTPA, TPP1), a cytosolic protein highly expressed in liver and placenta (Arita et al. 1995, Kostner et al. 1995). The main function of TTPA is to maintain normal alpha-TOH concentrations in the plasma and extrahepatic tissues by binding to, and facilitating the transport of, alpha-TOH from lysosomes to the plasma membrane (Qian et al. 2005; reviews Kono & Arai 2015, Schmolz et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
16024914	Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein Manor, D, Qian, J, Atkinson, J, Nava, P, Wilson, K, Morley, S	J. Lipid Res.	2005
26981194	Complexity of vitamin E metabolism Birringer, M, Lorkowski, S, Wallert, M, Schmölz, L	World J Biol Chem	2016
7832785	Human plasma phospholipid transfer protein accelerates exchange/transfer of alpha-tocopherol between lipoproteins and cells Dieplinger, H, Kostner, GM, Jauhiainen, M, Ehnholm, C, Esterbauer, H, Oettl, K	Biochem. J.	1995
25262571	Intracellular transport of fat-soluble vitamins A and E Kono, N, Arai, H	Traffic	2015
7887897	Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization Sato, Y, Arai, H, Arita, M, Takahashi, E, Miyata, A, Kayden, HJ, Inoue, K, Tanabe, T	Biochem. J.	1995