TTPA binds alpha-TOH

Stable Identifier
R-HSA-8874718
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Alpha-tocopherol (alpha-TOH) belongs to the fat-soluble vitamin E family and is the major form used by humans as an important antioxidant of plasma lipoproteins and cell membranes. It is secreted from the liver into the blood stream but as it is a lipophilic compound, it requires intracellular binding proteins to bind and transport it to exert its actions. One such protein is alpha-tocopherol transfer protein (TTPA, TPP1), a cytosolic protein highly expressed in liver and placenta (Arita et al. 1995, Kostner et al. 1995). The main function of TTPA is to maintain normal alpha-TOH concentrations in the plasma and extrahepatic tissues by binding to, and facilitating the transport of, alpha-TOH from lysosomes to the plasma membrane (Qian et al. 2005; reviews Kono & Arai 2015, Schmolz et al. 2016).

Literature References
PubMed ID Title Journal Year
26981194 Complexity of vitamin E metabolism

Schmölz, L, Birringer, M, Lorkowski, S, Wallert, M

World J Biol Chem 2016
16024914 Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein

Qian, J, Morley, S, Wilson, K, Nava, P, Atkinson, J, Manor, D

J. Lipid Res. 2005
7832785 Human plasma phospholipid transfer protein accelerates exchange/transfer of alpha-tocopherol between lipoproteins and cells

Kostner, GM, Oettl, K, Jauhiainen, M, Ehnholm, C, Esterbauer, H, Dieplinger, H

Biochem. J. 1995
25262571 Intracellular transport of fat-soluble vitamins A and E

Kono, N, Arai, H

Traffic 2015
7887897 Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization

Arita, M, Sato, Y, Miyata, A, Tanabe, T, Takahashi, E, Kayden, HJ, Arai, H, Inoue, K

Biochem. J. 1995
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