The N-terminal domain of CREB3L4 (CREB4, AIbZIP) containing the bZIP and transcription activation domains trafficks from the cytosol to the nucleus (Stirling and O'Hare 2006, inferred from mouse Creb3l4 (Tisp40)) where it activates transcription of target genes such as HSPA5 (BiP), BAG3, DNAJC12, and KDELR3 (Qi et al. 2002, Ben Aicha et al. 2007). Expression of CREB3L4 is itself induced by androgens in prostate tissue (Qi et al. 2002).