CREB3L4 translocates from the cytosol to the nucleus

Stable Identifier
R-HSA-8874218
Type
Reaction [omitted]
Species
Homo sapiens
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The N-terminal domain of CREB3L4 (CREB4, AIbZIP) containing the bZIP and transcription activation domains trafficks from the cytosol to the nucleus (Stirling and O'Hare 2006, inferred from mouse Creb3l4 (Tisp40)) where it activates transcription of target genes such as HSPA5 (BiP), BAG3, DNAJC12, and KDELR3 (Qi et al. 2002, Ben Aicha et al. 2007). Expression of CREB3L4 is itself induced by androgens in prostate tissue (Qi et al. 2002).

Literature References
PubMed ID Title Journal Year
11830526 AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells

Qi, H, Fillion, C, Labrie, Y, Grenier, J, Fournier, A, Berger, L, El-Alfy, M, Labrie, C

Cancer Res. 2002
17712038 Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells

Ben Aicha, S, Lessard, J, Pelletier, M, Fournier, A, Calvo, E, Labrie, C

Physiol. Genomics 2007
16236796 CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P

Stirling, J, O'Hare, P

Mol. Biol. Cell 2006
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