CREB3L4 translocates from the endoplasmic reticulum membrane to the Golgi membrane

Stable Identifier
R-HSA-8874209
Type
Reaction [omitted]
Species
Homo sapiens
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CREB3L4 (CREB4) is observed in the endoplasmic reticulum (ER) and the Golgi (Stirling and O'Hare 2006). Based on homologous transcription factors possessing transmembrane domains, CREB3L4 is inferred to traffic from the ER to the Golgi where it is activated by cleavage. Stress caused by dithiothreitol causes trafficking of CREB3L4 to the Golgi but cleavage by MBTPS1 (S1P) is not observed (Stirling and O'Hare 2006).

Literature References
PubMed ID Title Journal Year
16236796 CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P

Stirling, J, O'Hare, P

Mol. Biol. Cell 2006
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