Unlike ATF6, CREB3L3 (and probably other CREB3 family members) does not interact with HSPA5 (BiP) (Llarena 2010). Instead, retention in the endoplasmic reticulum (ER) is mediated by a membrane-proximal cytoplasmic motif (Bailey et al. 2007). When the motif is deleted CREB3L3 is constitutively trafficked to the Golgi where it is cleaved (Bailey et al. 2007). In cells not experiencing ER stress, CREB3L3 is located in the ER membrane (Stirling and O'Hare 2006, Bailey et al. 2007, Llarena et al. 2010) and is rapidly turned over by the endoplasmic reticulum associated degradation (ERAD) pathway (Bailey et al. 2007). During ER stress CREB3L3 is translocated by an uncharacterized mechanism to the Golgi (Bailey et al. 2007, Llarena et al. 2010, also inferred from the mouse homolog in Zhang et al. 2006). CREB3L3 is expressed strongly in the liver and more weakly in the stomach and small intestine.