MBTPS1 (S1P) cleaves CREB3L3

Stable Identifier
R-HSA-8874206
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CREB3L3 at the Golgi membrane is cleaved in the luminal domain (LLarena et al. 2010) by MBTPS1 (S1P) (Bailey et al. 2007, inferred from mouse homologs in Zhang et al. 2006). By inference from cleavage of SREBFs (SREBPs), CREB3L3 is believed to be cleaved at a RTLH motif at amino acid residue 364.

Literature References
PubMed ID Title Journal Year
19883396 Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6

Llarena, M, Bailey, D, Curtis, H, O'Hare, P

Traffic 2010
16469704 Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Zhang, K, Shen, X, Wu, J, Sakaki, K, Saunders, T, Rutkowski, DT, Back, SH, Kaufman, RJ

Cell 2006
17875199 Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis

Bailey, D, Barreca, C, O'Hare, P

Traffic 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!