Reactome | MBTPS1 (S1P) cleaves CREB3L3

MBTPS1 (S1P) cleaves CREB3L3

Stable Identifier

R-HSA-8874206

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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CREB3L3 at the Golgi membrane is cleaved in the luminal domain (LLarena et al. 2010) by MBTPS1 (S1P) (Bailey et al. 2007, inferred from mouse homologs in Zhang et al. 2006). By inference from cleavage of SREBFs (SREBPs), CREB3L3 is believed to be cleaved at a RTLH motif at amino acid residue 364.

Literature References

PubMed ID	Title	Journal	Year
16469704	Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response Zhang, K, Shen, X, Wu, J, Sakaki, K, Saunders, T, Rutkowski, DT, Back, SH, Kaufman, RJ	Cell	2006
19883396	Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6 Llarena, M, Bailey, D, Curtis, H, O'Hare, P	Traffic	2010
17875199	Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis Bailey, D, Barreca, C, O'Hare, P	Traffic	2007