MBTPS1 (S1P) cleaves CREB3L3

Stable Identifier
Reaction [transition]
Homo sapiens
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CREB3L3 at the Golgi membrane is cleaved in the luminal domain (LLarena et al. 2010) by MBTPS1 (S1P) (Bailey et al. 2007, inferred from mouse homologs in Zhang et al. 2006). By inference from cleavage of SREBFs (SREBPs), CREB3L3 is believed to be cleaved at a RTLH motif at amino acid residue 364.

Literature References
PubMed ID Title Journal Year
16469704 Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Kaufman, RJ, Zhang, K, Back, SH, Shen, X, Sakaki, K, Wu, J, Rutkowski, DT, Saunders, T

Cell 2006
19883396 Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6

O'Hare, P, Bailey, D, Curtis, H, Llarena, M

Traffic 2010
17875199 Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis

O'Hare, P, Bailey, D, Barreca, C

Traffic 2007
Catalyst Activity

serine-type endopeptidase activity of MBTPS1 [Golgi membrane]

Orthologous Events
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