MBTPS1 (S1P) cleaves CREB3L2

Stable Identifier
R-HSA-8874205
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MBTPS1 (S1P) cleaves CREB3L2 in the luminal domain. By inference from SREBFs (SREBPs) the cleavage is believed to occur at a RNLL motif at amino acid residue 430. The N-terminal product remains attached to the Golgi membrane by its transmembrane domain. The C-terminal luminal domain is eventually secreted and promotes Hedgehog signaling (Iwamoto et al. 2015).

Literature References
PubMed ID Title Journal Year
25955804 Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7

Iwamoto, H, Matsuhisa, K, Saito, A, Kanemoto, S, Asada, R, Hino, K, Takai, T, Cui, M, Cui, X, Kaneko, M, Arihiro, K, Sugiyama, K, Kurisu, K, Matsubara, A, Imaizumi, K

PLoS ONE 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created