MBTPS1 (S1P) cleaves CREB3L2 in the luminal domain. By inference from SREBFs (SREBPs) the cleavage is believed to occur at a RNLL motif at amino acid residue 430. The N-terminal product remains attached to the Golgi membrane by its transmembrane domain. The C-terminal luminal domain is eventually secreted and promotes Hedgehog signaling (Iwamoto et al. 2015).
Imaizumi, K, Sugiyama, K, Matsubara, A, Kanemoto, S, Saito, A, Asada, R, Arihiro, K, Cui, M, Kaneko, M, Takai, T, Hino, K, Cui, X, Kurisu, K, Iwamoto, H, Matsuhisa, K
serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
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