MBTPS1 (S1P) cleaves CREB3

Stable Identifier
Reaction [transition]
Homo sapiens
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In the Golgi membrane, CREB3 (LUMAN) is cleaved by regulated intramembrane proteolysis (Raggo et al. 2002, Liang et al. 2006, Stirling and O'Hare 2006, Eleveld-Trancikova et al. 2010). As inferred from other cleaved proteins, the reaction is probably catalyzedby MBTPS1 (S1P) at an RQLR motif (Stirling and O'Hare 2006).
Literature References
PubMed ID Title Journal Year
20546900 DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation

van Hout-Kuijer, MA, Eleveld-Trancikova, D, Jansen, BJ, Sanecka, A, Adema, GJ, Hendriks, IA, Looman, MW

Mol. Immunol. 2010
16940180 Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element

Lu, R, Martyn, AC, Dean, JD, Cockram, GP, Kokame, K, Li, Y, Audas, TE, Liang, G

Mol. Cell. Biol. 2006
12138176 Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis

O'Hare, P, Raggo, C, Gobeil, P, Misra, V, Smith-Windsor, E, Stirling, J, Rapin, N

Mol. Cell. Biol. 2002
16236796 CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P

O'Hare, P, Stirling, J

Mol. Biol. Cell 2006
Catalyst Activity

serine-type endopeptidase activity of MBTPS1 [Golgi membrane]

Orthologous Events
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