MBTPS2 (S2P) cleaves CREB3L3

Stable Identifier
R-HSA-8874201
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After cleavage by MBTPS1, CREB3L3 in the Golgi membrane is cleaved by MBTPS2 (S2P) near the cytoplasmic face of the transmembrane domain (Bailey et al. 2007, inferred from mouse homologs in Zhang et al. 2006). By inference from cleavage of SREBFs (SREBPs), CREB3L3 is believed to be cleaved at approximately amino acid residue 323. The cleavage releases the N-terminal cytoplasmic domain into the cytosol.

Literature References
PubMed ID Title Journal Year
17875199 Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis

Bailey, D, Barreca, C, O'Hare, P

Traffic 2007
16469704 Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Zhang, K, Shen, X, Wu, J, Sakaki, K, Saunders, T, Rutkowski, DT, Back, SH, Kaufman, RJ

Cell 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MBTPS2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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