CREB3 is expressed ubiquitously (Lu et al. 1997) and associates in the endoplasmic reticulum (ER) membrane (Stirling and O'Hare 2006) with DCSTAMP (Eleveld-Trancikova et al. 2010). Through an unclear mechanism, that may involve association of OS9 with unfolded proteins, CREB3 and DCSTAMP, which may remain in a complex, transit from the ER membrane to the Golgi membrane where CREB3 is activated by cleavage (Eleveld-Trancikova et al. 2010). CREB3 becomes activated during maturation of dendritic cells induced by lipopolysaccharide and cytokines (Eleveld-Trancikova et al. 2010).
O'Hare, P, Lu, R, Misra, V, Yang, P
van Hout-Kuijer, MA, Eleveld-Trancikova, D, Jansen, BJ, Sanecka, A, Adema, GJ, Hendriks, IA, Looman, MW
O'Hare, P, Stirling, J
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