Reactome | CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane

CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane

Stable Identifier

R-HSA-8874200

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

Golgi membrane, endoplasmic reticulum membrane

ReviewStatus

5/5

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CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane

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CREB3 is expressed ubiquitously (Lu et al. 1997) and associates in the endoplasmic reticulum (ER) membrane (Stirling and O'Hare 2006) with DCSTAMP (Eleveld-Trancikova et al. 2010). Through an unclear mechanism, that may involve association of OS9 with unfolded proteins, CREB3 and DCSTAMP, which may remain in a complex, transit from the ER membrane to the Golgi membrane where CREB3 is activated by cleavage (Eleveld-Trancikova et al. 2010). CREB3 becomes activated during maturation of dendritic cells induced by lipopolysaccharide and cytokines (Eleveld-Trancikova et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
9271389	Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor Lu, R, Yang, P, O'Hare, P, Misra, V	Mol. Cell. Biol.	1997
20546900	DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation Eleveld-Trancikova, D, Sanecka, A, van Hout-Kuijer, MA, Looman, MW, Hendriks, IA, Jansen, BJ, Adema, GJ	Mol. Immunol.	2010
16236796	CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P Stirling, J, O'Hare, P	Mol. Biol. Cell	2006