CREB3L2 translocates from the endoplasmic reticulum membrane to the Golgi membrane

Stable Identifier
Reaction [omitted]
Homo sapiens
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CREB3L2 (BBF2H7) localizes to the endoplasmic reticulum (Panagopoulos et al. 2007, Kondo et al. 2012) of cells in cartilage, lungs, spleen, gonads, and nervous system where it is normally targeted for proteolytic degradation by HRD1 (inferred from mouse homologs). During ER stress, CREB3L2 becomes stabilized and traffics by an uncharacterized mechanism to the Golgi membrane where it is activated by cleavage (inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
22705851 Activation of OASIS family, ER stress transducers, is dependent on its stabilization

Iwamoto, H, Hino, SI, Oki, M, Nomura, Y, Miyagi, H, Urano, F, Saito, A, Kaneko, M, Izumi, S, Imaizumi, K, Kawasaki, N, Kanemoto, S, Kondo, S, Asada, R

Cell Death Differ. 2012
17117415 Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera

Mandahl, N, Vlamis-Gardikas, A, Panagopoulos, I, Möller, E, Isaksson, M, Dahlén, A, Mertens, F

Genes Chromosomes Cancer 2007
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