MBTPS2 (S2P) cleaves CREB3L4

Stable Identifier
R-HSA-8874195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MBTPS2 (S2P) cleaves CREB3L4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CREB3L4 (CREB4) is cleaved near the cytoplasmic face of the transmembrane domain (Stirling and O'Hare 2006, Ben-Aicha et al. 2007). Based on homology with the mouse homolog and other CREB3 proteins, MBTPS2 (S2P) cleaves CREB3L4 and the cleavage is inferred to occur at approximately amino acid 297. The cleavage releases the N-terminal domain to the cytosol.

Literature References
PubMed ID Title Journal Year
17712038 Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells

Lessard, J, Fournier, A, Ben Aicha, S, Pelletier, M, Labrie, C, Calvo, E

Physiol. Genomics 2007
16236796 CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P

O'Hare, P, Stirling, J

Mol. Biol. Cell 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of MBTPS2 [Golgi membrane]

Physical Entity
MBTPS2 [Golgi membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Mbtps2 (S2P) cleaves Creb3l4 (Mus musculus)
Authored
May, B  (2016-05-21)
Reviewed
Schröder, M  (2017-02-25)
Created
May, B  (2016-05-21)
Cite Us!