MBTPS1 (S1P) cleaves CREB3L4

Stable Identifier
R-HSA-8874186
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane
ReviewStatus
5/5
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MBTPS1 (S1P) cleaves CREB3L4
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MBTPS1 (S1P) cleaves the lumenal domain of CREB3L4 (Stirling and O'Hare 2006, Ben-Aicha et al. 2007). Based on homology with SREBFs (SREBPs), other CREB3 proteins, and the mouse homolog Creb3l4 (Tisp40) the cleavage site is inferred to be at a RNIL motif at amino acid 338. The C-terminal domain of CREB3L4 interferes with cleavage and therefore may regulate the process (Stirling and O'Hare 2006). Dithiothreitol (DTT) causes trafficking but not cleavage of CREB3L4.
Literature References
PubMed ID Title Journal Year
17712038 Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells

Lessard, J, Fournier, A, Ben Aicha, S, Pelletier, M, Labrie, C, Calvo, E

Physiol. Genomics 2007
16236796 CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P

O'Hare, P, Stirling, J

Mol. Biol. Cell 2006
Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of MBTPS1 [Golgi membrane]

Physical Entity
MBTPS1 [Golgi membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Mbtps1 (S1P) cleaves Creb3l4 (Mus musculus)
Authored
May, B  (2016-05-21)
Reviewed
Schröder, M  (2017-02-25)
Created
May, B  (2016-05-21)
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