Reactome | MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)

MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)

Stable Identifier

R-HSA-8874122

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

3/5

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MBTPS2 (S2P) cleaves the transmembrane domain of ATF6B near the cytoplasmic face, releasing the N-terminal cytoplasmic domain into the cytosol (Haze et al. 2001, Guan et al. 2009, Odisho et al. 2015). By inference from SREBFs (SREBPs) and ATF6, the cleavage is believed to occur around amino acid residue 399. Glycosylation of 5 sites in the lumenal domain of ATF6B is required for cleavage (Guan et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19693772	N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha Yang, M, Li, VE, Shen, Z, Wang, H, Xu, Y, Guan, D	J. Cell. Biochem.	2009
11256944	Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response Mori, K, Yura, T, Negishi, M, Yanagi, H, Okada, T, Yoshida, H, Haze, K	Biochem. J.	2001
25447309	ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells Zhang, L, Odisho, T, Volchuk, A	Exp. Cell Res.	2015