PTK2 autophosphorylates

Stable Identifier
R-HSA-8874078
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PTK2 autophosphorylates
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding to activated MET promotes PTK2 (FAK1) autophosphorylation at tyrosine residue Y397, a step involved in HGF-triggered cell migration (Chen and Chen 2006). It was demonstrated that PTK2 may associate with activated MET as a homodimer and that autophosphorylation at Y397 of PTK2 may happen in trans (Brami-Cherrier et al. 2014).

Literature References
PubMed ID Title Journal Year
16782899 Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion

Chen, SY, Chen, HC

Mol. Cell. Biol. 2006
24480479 FAK dimerization controls its kinase-dependent functions at focal adhesions

Brami-Cherrier, K, Gervasi, N, Arsenieva, D, Walkiewicz, K, Boutterin, MC, Ortega, A, Leonard, PG, Seantier, B, Gasmi, L, Bouceba, T, Kadaré, G, Girault, JA, Arold, ST

EMBO J. 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of HGF:p-4Y-MET dimer:PTK2 [plasma membrane]
Physical Entity
HGF:p-4Y-MET dimer:PTK2 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
PTK2 autophosphorylates (Danio rerio)
PTK2 autophosphorylates (Gallus gallus)
PTK2 autophosphorylates (Mus musculus)
PTK2 autophosphorylates (Rattus norvegicus)
PTK2 autophosphorylates (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-05-20)