Binding to activated MET promotes PTK2 (FAK1) autophosphorylation at tyrosine residue Y397, a step involved in HGF-triggered cell migration (Chen and Chen 2006). It was demonstrated that PTK2 may associate with activated MET as a homodimer and that autophosphorylation at Y397 of PTK2 may happen in trans (Brami-Cherrier et al. 2014).
Bouceba, T, Gasmi, L, Leonard, PG, Gervasi, N, Walkiewicz, K, Boutterin, MC, Brami-Cherrier, K, Seantier, B, Arsenieva, D, Arold, ST, Ortega, A, Kadaré, G, Girault, JA
Chen, HC, Chen, SY
protein tyrosine kinase activity of HGF:p-4Y-MET dimer:PTK2 [plasma membrane]
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