PTK2 autophosphorylates

Stable Identifier
R-HSA-8874078
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Binding to activated MET promotes PTK2 (FAK1) autophosphorylation at tyrosine residue Y397, a step involved in HGF-triggered cell migration (Chen and Chen 2006). It was demonstrated that PTK2 may associate with activated MET as a homodimer and that autophosphorylation at Y397 of PTK2 may happen in trans (Brami-Cherrier et al. 2014).

Literature References
PubMed ID Title Journal Year
16782899 Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion

Chen, SY, Chen, HC

Mol. Cell. Biol. 2006
24480479 FAK dimerization controls its kinase-dependent functions at focal adhesions

Brami-Cherrier, K, Gervasi, N, Arsenieva, D, Walkiewicz, K, Boutterin, MC, Ortega, A, Leonard, PG, Seantier, B, Gasmi, L, Bouceba, T, Kadaré, G, Girault, JA, Arold, ST

EMBO J. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of HGF:p-4Y-MET dimer:PTK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created