PTK2 autophosphorylates

Stable Identifier
R-HSA-8874078
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding to activated MET promotes PTK2 (FAK1) autophosphorylation at tyrosine residue Y397, a step involved in HGF-triggered cell migration (Chen and Chen 2006). It was demonstrated that PTK2 may associate with activated MET as a homodimer and that autophosphorylation at Y397 of PTK2 may happen in trans (Brami-Cherrier et al. 2014).

Literature References
PubMed ID Title Journal Year
24480479 FAK dimerization controls its kinase-dependent functions at focal adhesions

Bouceba, T, Gasmi, L, Leonard, PG, Gervasi, N, Walkiewicz, K, Boutterin, MC, Brami-Cherrier, K, Seantier, B, Arsenieva, D, Arold, ST, Ortega, A, Kadaré, G, Girault, JA

EMBO J. 2014
16782899 Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion

Chen, HC, Chen, SY

Mol. Cell. Biol. 2006
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of HGF:p-4Y-MET dimer:PTK2 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!