Reactome | OTUD3 deubiquitinates PTEN

OTUD3 deubiquitinates PTEN

Stable Identifier

R-HSA-8873946

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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OTUD3 de-polyubiquitylates and stabilizes PTEN, effectively removing Lys 48-linked polyubiquitylation, but not monoubiquitylation nor the non-degradative Lys 63-linked polyubiquitylation of PTEN. In vitro OTUD3 efficiently removed the Lys 6, Lys 11, Lys 27 and Lys 48 types of ubiquitin chain on PTEN (Yuan et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26280536	Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis Lv, Y, Zhang, Y, Xiao, ZX, Song, S, Xing, G, Gao, H, Li, H, Zhou, T, Wei, W, Kong, X, Yin, Y, Wang, L, He, F, Gao, D, Li, Y, Yuan, L, Zhang, L	Nat. Cell Biol.	2015