Reactome | Casein kinase II phosphorylates STARD10

Casein kinase II phosphorylates STARD10

Stable Identifier

R-HSA-8873929

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PCTP-like protein (STARD10) is a member of the steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins that are implicated in lipid transport, metabolism, and signaling. STARD10 is thought to function as a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine and phosphatidylethanolamine between membranes. Its lipid transfer activity is negatively regulated by casein kinase, a serine/threonine-protein kinase which phosphorylates STARD10 on a serine residue at position 284 (Olayioye et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17561512	Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity Olayioye, MA, Buchholz, M, Schmid, S, Schoffler, P, Hoffmann, P, Pomorski, T	J. Biol. Chem.	2007