STARD7 transports PC from ER membrane to mitochondrial outer membrane

Stable Identifier
R-HSA-8873830
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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STARD7 transports PC from ER membrane to mitochondrial outer membrane
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The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. Human StAR-related lipid transfer protein 7 (STARD7, aka GTT1) is a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily that can bind phospholipids and sphingolipids (Flores-Martin et al. 2013). It was first identified as a gene overexpressed in a choriocarcinoma cell line (Durand et al. 2004). Human STARD7 is thought to transport phosphatidylcholine (PC) from ER membranes to mitochondrial membranes, inferred from rat experiments (Horibata & Sugimoto 2010). Increasing evidence suggests that asthma pathogenesis is linked to mitochondrial dysfunction and STARD7 could play a protective role in mucosal tissues by preventing pathogenic immune responses (Yang et al. 2015).
Literature References
PubMed ID Title Journal Year
25980009 Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin

Apsley, K, Weaver, TE, Wills-Karp, M, Fritz, JM, Yang, L, Lewkowich, I

J. Immunol. 2015
23507753 The Lipid Transfer Protein StarD7: Structure, Function, and Regulation

Angeletti, S, Rena, V, Panzetta-Dutari, GM, Genti-Raimondi, S, Flores-Martin, J

Int J Mol Sci 2013
15013637 GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization

Durand, S, Angeletti, S, Genti-Raimondi, S

Placenta 2004
20042613 StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria

Horibata, Y, Sugimoto, H

J. Biol. Chem. 2010
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Stard7 transports PC from ER membrane to mitochondrial outer membrane (Rattus norvegicus)
Authored
Jassal, B  (2016-05-20)
Reviewed
D'Eustachio, P  (2016-07-15)
Created
Jassal, B  (2016-05-20)
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