STARD7 transports PC from ER membrane to mitochondrial outer membrane

Stable Identifier
R-HSA-8873830
Type
Reaction [omitted]
Species
Homo sapiens
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The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. Human StAR-related lipid transfer protein 7 (STARD7, aka GTT1) is a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily that can bind phospholipids and sphingolipids (Flores-Martin et al. 2013). It was first identified as a gene overexpressed in a choriocarcinoma cell line (Durand et al. 2004). Human STARD7 is thought to transport phosphatidylcholine (PC) from ER membranes to mitochondrial membranes, inferred from rat experiments (Horibata & Sugimoto 2010). Increasing evidence suggests that asthma pathogenesis is linked to mitochondrial dysfunction and STARD7 could play a protective role in mucosal tissues by preventing pathogenic immune responses (Yang et al. 2015).

Literature References
PubMed ID Title Journal Year
23507753 The Lipid Transfer Protein StarD7: Structure, Function, and Regulation

Flores-Martin, J, Rena, V, Angeletti, S, Panzetta-Dutari, GM, Genti-Raimondi, S

Int J Mol Sci 2013
25980009 Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin

Yang, L, Lewkowich, I, Apsley, K, Fritz, JM, Wills-Karp, M, Weaver, TE

J. Immunol. 2015
15013637 GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization

Durand, S, Angeletti, S, Genti-Raimondi, S

Placenta 2004
20042613 StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria

Horibata, Y, Sugimoto, H

J. Biol. Chem. 2010
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