Reactome | SORL1 [endosome membrane]

SORL1 [endosome membrane]

Stable Identifier

R-HSA-8871475

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Sortilin-related receptor, SORL_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P20042 EIF2S2

Expand all

External Reference Information

External Reference

UniProt:Q92673 SORL1

Gene Names

SORL1, C11orf32

Chain

signal peptide:1-28, propeptide:29-81, chain:82-2214

Reference Genes

BioGPS Gene:6653 SORL1

COSMIC (genes):SORL1 SORL1

CTD Gene:6653 SORL1

dbSNP Gene:6653 SORL1

ENSEMBL:ENSG00000137642 SORL1

ENSEMBL_homo_sapiens_GENE:ENSG00000137642.13 SORL1

HGNC:11185 SORL1

KEGG Gene (Homo sapiens):6653 SORL1

Monarch:6653 SORL1

NCBI Gene:6653 SORL1

OMIM:602005 SORL1

UCSC:Q92673 SORL1

Reference Transcript

RefSeq:NM_003105.5 SORL1

Other Identifiers

11743129_at

11743130_a_at

16732584

203509_PM_at

203509_at

212560_PM_at

212560_at

32140_at

3352949

3352950

3352962

3352963

3352977

3352978

3352982

3352983

3352985

3352986

3352989

3352990

3352992

3352998

3353005

3353009

3353011

3353013

3353015

3353016

3353018

3353020

3353021

3353022

3353026

3353027

3353030

3353033

3353037

3353038

3353039

3353041

3353043

3353044

3353045

3353047

3353048

3353049

3353050

3353051

3353052

3353053

3353057

3353060

3353062

3353063

3353064

3353065

3353066

3353069

3353073

3353075

3353076

3353077

3353078

3353079

3353080

3564202

38411_at

6653

7944667

90218_at

A_14_P120661

A_14_P138519

A_23_P87049

GE59554

GE79051

GO:0000139

GO:0001540

GO:0002024

GO:0004888

GO:0005041

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005641

GO:0005768

GO:0005769

GO:0005771

GO:0005783

GO:0005789

GO:0005794

GO:0005802

GO:0005886

GO:0006605

GO:0006622

GO:0006629

GO:0006886

GO:0006892

GO:0006897

GO:0006898

GO:0007218

GO:0009986

GO:0010008

GO:0010897

GO:0014910

GO:0016020

GO:0016192

GO:0016477

GO:0019828

GO:0023052

GO:0030154

GO:0030163

GO:0030169

GO:0030514

GO:0030658

GO:0031267

GO:0031333

GO:0031410

GO:0031901

GO:0031985

GO:0032585

GO:0034067

GO:0038020

GO:0038024

GO:0042923

GO:0043025

GO:0043226

GO:0045053

GO:0045732

GO:0046628

GO:0048856

GO:0048870

GO:0050768

GO:0051604

GO:0055037

GO:0055038

GO:0060089

GO:0065003

GO:0070062

GO:0070863

GO:0072659

GO:0097356

GO:0098772

GO:0099638

GO:1900168

GO:1902430

GO:1902953

GO:1902955

GO:1902966

GO:1902992

GO:1902997

GO:1904179

GO:1990845

GO:2001137

HMNXSV003029070

Hs.82845.0.S1_3p_at

ILMN_1759818

ILMN_2060115

PH_hs_0025655

TC11001107.hg

TC11002916.hg

U60975_at

U90916_at

g6325473_3p_at

Participates

as a component of

SORL1:APP(18-770) [endosome lumen] (Homo sapiens)

as an input of

SORL1 binds APP(18-770) (Homo sapiens)

Other forms of this molecule

SORL1 [Golgi membrane]

Cross References

RefSeq

NP_003096.1

OpenTargets

ENSG00000137642

HPA

ENSG00000137642-SORL1

GeneCards

Q92673

Ensembl

ENSG00000137642, ENSP00000260197, ENST00000260197

PRO

Q92673

Pharos - Targets

Q92673

Orphanet

21201

PDB

3WSZ, 7VT0, 3WSY, 3WSX, 3G2T, 3G2S, 2DM4

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92673-PRO_0000033164 SORL1			0.813	9
UniProt:P30533 AMRP			0.8	5
UniProt:Q9UJY4 GGA2	2	GGA2 [early endosome membrane] (R-HSA-8854140) GGA2 [endosome membrane] (R-HSA-5692937)	0.774	6
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.744	5
UniProt:P05067-4 APP	2	APP (535-695) [cytosol] (R-HSA-9839084) APP [mitochondrial inner membrane] (R-HSA-9839060)	0.727	8
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.69	5
UniProt:P26992 CNTFR	1	CNTFR [plasma membrane] (R-HSA-5696438)	0.672	7
UniProt:P08887 IL6R	1	IL6R [plasma membrane] (R-HSA-197824)	0.619	7
UniProt:P05067-PRO_0000000093 APP			0.618	3
UniProt:P39905-PRO_0000034005 GDNF			0.571	6
UniProt:P05231 IL6	3	IL6 [extracellular region] (R-HSA-447100) IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044)	0.571	4
UniProt:Q62997 Gfra1	2	GFRalpha-1 [plasma membrane] (R-RNO-420354) Gfra1 [plasma membrane] (R-RNO-375067)	0.567	5
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P20042 EIF2S2	1	EIF2S2 [cytosol] (R-HSA-72512)	0.556	3
UniProt:P43681 CHRNA4	1	CHRNA4 [plasma membrane] (R-HSA-507836)	0.556	3
UniProt:P78424 PO6F2			0.556	3
IntAct:EBI-25857140 ORF			0.556	3
IntAct:EBI-16882364 CALM1			0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P00491 PNP	7	PNP R234P [cytosol] (R-HSA-9735772) PNP E89K [cytosol] (R-HSA-9735781) PNP D128G [cytosol] (R-HSA-9735785) PNP [secretory granule lumen] (R-HSA-6803318) PNP [extracellular region] (R-HSA-6806505) PNP [ficolin-1-rich granule lumen] (R-HSA-6803278) PNP [cytosol] (R-HSA-61933)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.556	3
UniProt:Q15669 RHOH	1	RHOH [plasma membrane] (R-HSA-194859)	0.556	3
UniProt:Q8N0S8 Q8N0S8			0.556	3
UniProt:P05067-8 APP			0.554	2
UniProt:P56159-2 GFRA1			0.544	3
UniProt:O75462 CRLF1	2	CRLF1 [cytosol] (R-HSA-8950296) CRLF1 [extracellular region] (R-HSA-5693174)	0.544	3
UniProt:O43301 HSPA12A	2	HSPA12A [cytosol] (R-HSA-5252017) HSPA12A [nucleoplasm] (R-HSA-5252130)	0.543	5
UniProt:O00214 LEG8			0.527	2
UniProt:Q6ZMY9 ZNF517	1	ZNF517 [nucleoplasm] (R-HSA-1973869)	0.527	2
UniProt:Q3SY56 SP6			0.527	3
UniProt:Q86Y25 ZNF354C	1	ZNF354C [nucleoplasm] (R-HSA-1247525)	0.527	2
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.527	3
UniProt:Q14929 ZNF169	1	ZNF169 [nucleoplasm] (R-HSA-975014)	0.527	2
UniProt:Q8TA94 ZNF563	1	ZNF563 [nucleoplasm] (R-HSA-1973875)	0.527	2
UniProt:O43296 ZNF264	1	ZNF264 [nucleoplasm] (R-HSA-1027386)	0.527	3
UniProt:Q8TDD2 SP7	1	SP7 [nucleoplasm] (R-HSA-8939843)	0.527	2
UniProt:O95395 GCNT3	1	GCNT3 [Golgi membrane] (R-HSA-914013)	0.527	4
UniProt:Q9NZL3 ZNF224	1	ZNF224 [nucleoplasm] (R-HSA-1027352)	0.527	2
UniProt:P15408 FOSL2			0.527	3
UniProt:Q9NQX6 ZNF331	1	ZNF331 [nucleoplasm] (R-HSA-1247549)	0.527	3
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.527	3
UniProt:Q8N8Y5 ZFP41			0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586)	0.527	2
UniProt:Q6IPR3 TYW3	1	TYW3 [cytoplasm] (R-HSA-6782888)	0.527	3
UniProt:P05067-PRO_0000000091 APP			0.518	4
UniProt:O75462-PRO_0000011039 CRLF1			0.463	2

Cite Us!