Reactome | p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP

p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP

Stable Identifier

R-HSA-8871366

Type

Reaction [binding]

Species

Homo sapiens

Compartment

early endosome membrane

ReviewStatus

5/5

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p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP

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RUN and FYVE domain-containing protein 1 (RUFY1, aka RABIP4, ZFYVE12), together with Ras-related proteins RAB4A, 5 and 14, could play an important role in GLUT4 trafficking in adipocytes and skeletal muscle (Kitagishi & Matsuda 2013, Larance et al. 2005, Mari et al. 2006, Fouraux et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
16154996	Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking Larance, M, James, DE, Graham, M, Wasinger, V, van Dam, EM, Stöckli, J, Junutula, JR, Ramm, G, Simpson, F, Winata, S, Guilhaus, M	J. Biol. Chem.	2005
16522682	The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes Keslair, F, Gonzalez, T, Monzo, P, Le Marchand-Brustel, Y, Cormont, M, Mari, M, Kaddai, V	J. Cell. Sci.	2006
14617813	Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes van der Heijden, A, van der Sluijs, P, Ivan, V, Raymackers, J, Pruijn, GJ, Fouraux, MA, van Venrooij, WJ, van Suylekom, D, Deneka, M	Mol. Biol. Cell	2004
23519112	RUFY, Rab and Rap Family Proteins Involved in a Regulation of Cell Polarity and Membrane Trafficking Matsuda, S, Kitagishi, Y	Int J Mol Sci	2013